Ulcerative Colitis

Latest News

Risk for Severe COVID-19 Not Elevated in Patients with Inflammatory Bowel Disease

By

Jessica Nye, PhD

Patients with inflammatory bowel disease had a similar risk for and outcomes from coronavirus disease 2019 as those in the general population.

Vitamin D to Reduce Risk of Checkpoint Inhibitor–Related Colitis

By

Jonathan Goodman, MPhil

Vitamin D may be used to reduce the risk of immune checkpoint inhibitor-related colitis, as well as ulcerative colitis and graft-vs-host disease.

Standard Definition White Light Endoscopy Is an Inferior Surveillance Modality for UC

By

Jessica Nye, PhD

The majority of endoscopic modalities for ulcerative colitis (UC) neoplasia surveillance were similarly effective, but white light standard definition (WL SD) was the least so.

Psoriasis, Psoriatic Arthritis Associated With Inflammatory Bowel Disease and Other Gastrointestinal Illnesses

By

Meghna Rao

Researchers evaluated the association of psoriasis and psoriatic arthritis with inflammatory bowel disease and other gastrointestinal illnesses.

Guideline Issued on the Use of Probiotics for Managing GI Disorders

By

Cassandra Pardini, PharmD

Probiotics should only be recommended for specific patient populations since there is not enough evidence to support their use in the majority of digestive conditions, according to new clinical guidelines released by the American Gastroenterological Association (AGA) and recently published in Gastroenterology.

Abbreviated Inflammatory Bowel Disease Disability Index Deemed Valid

By

Jessica Nye, PhD

According to results from a large cohort validation study, IBD-Disk was reported to be both viable and reliable.

Fecal Microbiota Transplantation for Treatment of Recurrent C. difficile Effective in UC

By

Jennifer Mannheim

Researchers assessed the microbial profiles of patients with IBD with recurrent C. difficile infection.

Volatile Organic Compounds in the Stool: Markers of Inflammatory Bowel Disease

By

Jessica Nye, PhD

Measurement of fecal volatile organic compounds (VOC) was effective in identifying inflammatory bowel disease (IBD) biomarkers, but not for monitoring disease activity.

Associations Between Gastrointestinal Infection and New-Onset IBD

By

Dibash Kumar Das, PhD

Certain enteric pathogens are associated with higher risk of incident inflammatory bowel disease, while others are could be protective.

Filgotinib Associated With Clinical Remission in Ulcerative Colitis Study

By

Brian Park, PharmD

At week 10, filgotinib 200mg met the primary end point with a significantly higher proportion of patients achieving clinical remission compared with placebo.

Risk for Colorectal Cancer Relatively Low in Patients with Ulcerative Colitis

By

Emily Pond

The total lifetime risk for colorectal cancer (CRC) in patients with ulcerative colitis (UC) was comparable to that observed in the general population.

Long-Term Outcomes in Patients with Acute Severe Ulcerative Colitis Responding to IVS

By

Emily Pond

Patients with acute severe ulcerative colitis (ASUC) who responded to intravenous steroids (IVS) had a low rate of colectomy over 5 years of follow-up.

Infliximab Clearance Associated with Colectomy in Patients with Acute Severe Ulcerative Colitis

By

Dibash Kumar Das, PhD

Baseline infliximab clearance is a strong predictive factor for colectomy in hospitalized patients with acute severe UC receiving salvage therapy.

Ustekinumab Treatment of Ulcerative Colitis May Lead to Steroid-Free Remission

By

Jessica Nye, PhD

Ustekinumab treatment of moderate-to-severe ulcerative colitis (UC) was effective for some patients, according to recent research.

Ulcerative Colitis and Fecal Transplantation: Where are We Now?

By

Andy Kistler, MD, PharmD

It is thought that dysregulation of the gut microbiome could cause increased production of pro-inflammatory toxins that can predispose patients to the development of UC.

Segmental Histologic Normalization Does Not Improve Ulcerative Colitis Outcomes

By

Jessica Nye, PhD

Segmental histologic normalization did not improve clinical outcomes of ulcerative colitis.

Prognostic Biomarkers Predict Mucosal Healing in Patients With Ulcerative Colitis

By

Dibash Kumar Das, PhD

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios can be used to predict mucosal healing in patients with ulcerative colitis treated with anti-TNF in monotherapy.

Bacteremia Risk Higher in Older Patients Hospitalized With IBD

Older age is associated with an increased risk for bacteremia in hospitalized patients with inflammatory bowel disease.

Vedolizumab May Be More Efficacious Than Infliximab in Refractory UC

By

Lauren Dembeck, PhD

Clinical remission was more likely with vedolizumab vs infliximab in UC after failure of initial anti-TNF agent.

Etrasimod in UC: Promising Phase 2 Results

By

Andy Kistler, MD, PharmD

Researchers evaluated the efficacy and safety of etrasimod, an oral, selective sphingosine 1-phosphate receptor modulator in development for immune-mediated inflammatory disorders, in patients with moderate to severe ulcerative colitis.