Ulcerative Colitis

Latest News

Prevalence of Depression in IBD

By

Rita Aghjayan

Researchers assessed whether depression in the presence or absence of previous GI symptoms is associated with a future diagnosis of IBD.

Regular Use of PPIs May Increase Risk for IBD

By

Jessica Nye, PhD

Investigators evaluated the association between regular proton pump inhibitor use and the risk for inflammatory bowel disease and its subtypes.

Gene Expression Useful for Stratifying Risk for Disease Complications in Ulcerative Colitis

By

Bradley van Paridon

Investigators aimed to show the efficacy of transcriptome-wide association studies in predicting transcriptional risk scores for disease complications requiring colectomy in patients with ulcerative colitis.

Combination of Anti-Inflammatory Treatment and Microbiota Management May Be Optimal for UC

By

Colby Stong

Researchers sought to determine whether alternative stable states exist in the intestinal ecosystem and if they could affect remission from ulcerative colitis.

Ultra-Processed Foods Associated With Risk for CD

By

Emily Pond

Investigators analyzed the association between consumption of ultra-processed foods and risk for Crohn disease and ulcerative colitis.

PTG-100 Shows Proof-of-Concept Efficacy in Patients With Moderate to Severe Active UC

By

Colby Stong

Researchers investigated the preclinical characteristics, safety, pharmacokinetics, pharmacodynamics, and efficacy of PTG-100 in patients with moderate to severe UC.

Unclear Evidence On Abdominal Pain Management Among Patients With UC

By

Jessica Nye, PhD

Authors assessed the safety and efficacy of current methods for managing abdominal pain in patients with ulcerative colitis.

Exclusion Diet May Ease Refractory Ulcerative Colitis

An ulcerative colitis exclusion diet (UCED) shows promise as an independent therapy for patients with refractory disease.

Statins Identified as Potential Therapy for Ulcerative Colitis

The researchers found that atorvastatin treatment had the highest inverse correlation with the ulcerative colitis gene signature among non-oncolytic FDA-approved therapies.

AbbVie Seeks Approval of Upadacitinib for Ulcerative Colitis

By

Brian Park, PharmD

The applications are supported by data from two 2two phase 3 induction studies and one 1 maintenance study.

Dietary Patterns Influence Structure, Function of Gut Microbiome in IBD

By

Rita Aghjayan

Researchers described the evolution of dietary patterns and the outcomes they have on the gut microbiome, immune function, and inflammation in people with IBD.

IBD and Obesity: Is there a Connection?

By

C. Andrew Kistler, MD, PharmD

One key factor that has developed increasing research interest is the role of a patient’s BMI, specifically those with obesity (BMI > 30 kg/m2), in the development of IBD.

Reduced Diversity of Gut Microbiota Composition Associated With the Clinical Course of UC

By

Vincent Soreca

Researchers aimed to determine whether gut microbiota are associated with relapse and treatment response in patients with ulcerative colitis.

Supplemental Bifid Triple Viable Capsules Are Beneficial for UC

By

Colby Stong

Investigators examined the effect of mesalazine plus somatostatin and bifid triple viable capsules on plasma inflammatory factors and T cell frequency in patients with ulcerative colitis.

Machine Learning May Help Predict Efficacy of VDZ Treatment in Patients With UC

By

Colby Stong

Investigators assessed the efficacy of a machine learning tool that predicts steroid-free clinical remission in patients with ulcerative colitis receiving vedolizumab therapy.

Predictors of UC Relapse Following 5-ASA Dose Reduction

By

Emily Pond

Investigators outlined risk factors for ulcerative colitis relapse in patients undergoing dose reduction of oral 5-aminosalicylic acid.

IBD: Extraintestinal Manifestations

By

Jennifer Champagne, PharmD, RPh, BCPS

Investigators reviewed the current clinical presentations and treatment options for extraintestinal manifestations in patients with inflammatory bowel disease.

Pediatric Gastroenterologists Prefer Initial Withdrawal of Immunomodulator in Step-Down Process in PIBD

By

Colby Stong

Researchers assessed the practices favored by pediatric gastroenterologists for combination immunosuppression in patients with pediatric inflammatory bowel disease.

Ultrasound Detects Ulcerative Colitis Disease Activity

New index shows strong correlation with endoscopically determined disease activity

Summarizing the Biological Function and Current Clinical Understanding of CP

By

Emily Pond

Investigators reviewed the recent research on the biological function of calprotectin in inflammatory diseases.