Genetic Liability to Cigarette Smoking Associated With a Wide Range of Diseases
Cigarette smoking has a causal role in a spectrum of diseases, but has been linked with decreased risk of prostate cancer and Parkinson’s disease.
Esophagus
Dupilumab Demonstrates Benefit in Pediatric Eosinophilic Esophagitis Trial
The phase 3 EoE KIDS study included 102 children with active eosinophilic esophagitis based on histologic improvement meeting validated histologic criteria.
PPI, Food Elimination Diet Helps Achieve Remission in Eosinophilic Esophagitis
Researchers sought to determine if receiving combined treatment with a PPI and a food elimination diet could help patients with eosinophilic esophagitis achieve remission.
Survival Similar for Early, Delayed Surgery in Stage I Esophageal Cancer
Survival is similar with early versus delayed surgery in stage I esophageal cancer, while for stage II/III cancer, five-year survival is improved with early surgery.
FDA Approves First Treatment for Eosinophilic Esophagitis
The U.S. FDA approved the monoclonal antibody Dupixent (dupilumab) to treat eosinophilic esophagitis patients 12 years and older.
Eosinophilic Esophagitis Severity Index Linked to Clinical Features, Treatment Response
Researchers investigated the relationship between eosinophilic esophagitis at the time of diagnosis and disease severity, and the change in disease before and after treatment.
Combined Food Allergies, Eosinophilic Esophagitis May Weaken PPI Response
While food allergies may affect response to the medication, environmental allergies do not, the report says.
Esophageal Cancer and Barrett Esophagus Increasing in Middle-Aged Adults
Researchers examined the prevalence of Barrett esophagus and esophageal cancer according to young, middle-aged, and older adult age groups.
Model Predicts Recurrent Dysplasia After Successful Treatment for Early Barrett Esophagus
To survey patients after successful treatment, researchers developed a prediction model for recurrent dysplasia after eradication of Barrett esophagus.
Guidelines Updated for Barrett Esophagus Diagnosis, Management
The authors recommend that dysplasia of any grade detected on BE biopsies be confirmed by a second pathologist who has expertise in gastrointestinal pathology.
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