Helicobacter pylori Infection Associated With Early Gastric Cancer

Researchers assessed the correlation between Helicobacter pylori infection and biological characteristics of early gastric cancer.

Helicobacter pylori (HP) infection is related to the tumor site and mucosal inflammatory infiltration of early gastric cancer (EGC), with the degree of infection being positively correlated with the degree of invasion and malignancy of ECG, according to a retrospective analysis published in the Journal of Cancer.1

Data have demonstrated that EGC accounts for a large proportion of gastric cancer (GC),2 but there are few studies on the correlation between EGC and patients infected with HP. Therefore, researchers in China aimed to study the correlation between the biological characteristics of EGC and HP infection.1

A total of 111 cases were collected from patients diagnosed with EGC through endoscopic surgery or surgical procedures from January 2009 to October 2018. Among the HP negative group (n=64), there were statistically significant differences in tumor sites between the uninfected group and the previously infected group (P<.05).

Between the positive and negative groups, there were significant differences in monocyte infiltration and neutrophil infiltration (P<.05). In addition, differentiated adenocarcinoma in the positive group was significantly lower than in the negative group, while the incidence rate of mixed type cancer was significantly higher than that in the positive group (P<.01).

In the HP positive group, there was a statistically significant difference in human epidermal growth factor receptor 2 (HER2) between the unsterilized group and the previously sterilized group (P<.05). However, there was also a statistically significant difference in HER2 between the HP positive group and the HP negative group (P<.01). This indicates that HP infection is significantly correlated with HER2 index and presented as a positive correlation (P=.014).

The authors concluded by saying, “Furthermore, the tumor indicator HER2 is closely related to HP infection, and the detection of HP combined with HER2 is of great significance in the discovery of EGC and the evaluation of its malignancy.”1


1. Chao G, Chen X, Zhang S. Study on the correlation between Helicobacter pylori and biological characteristics of early gastric cancer. J Cancer. 2021;12(6):1838-45. doi: 10.7150/jca.46392

2.      Leung WK, Wu MS, Kakugawa Y, et al. Asia Pacific Working Group on Gastric Cancer. Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol. 2008;9(3):279-87. doi: 10.1016/S1470-2045(08)70072-X