Helicobacter pylori (H pylori) eradication may not be beneficial in certain diseases. For this reason, its elimination should be treated individually, based on H pylori antibody typing classification. These findings are based on the results of a study published in Scientific Reports.

In this retrospective analysis, researchers sought to assess the relationship between different types of H pylori infection on the distribution of histopathological characteristics and the levels of 3 items of serum gastric function.

From October 2018 to February 2020, 1175 inpatients were recruited for the study in the department of gastroenterology of Peoples Hospital of Xinjiang Uygur Autonomous Region.

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Inpatients were divided into 3 groups based on H pylori antibody typing classification: 235 inpatients were enrolled in the type II H pylori infection group and 470 inpatients were enrolled and divided into the type I H pylori infection group and the control group, respectively (1:2 paired). Among those enrolled, 630 were men and 545 were women. The average age was 55.9 + 9.4 years (range, 30-82 years).

Exclusion criteria included ethnic minorities and a history of previous gastric cancer. All inpatients underwent 14C-Urea breath tests (14C-Urea breath test, 14C-UBT), H pylori antibody typing classification, three items of serum gastric function detection (PGI, PGII, G-17), painless gastroscopy, and pathological examination.

Significant differences were observed among type I H pylori infection group, type II H pylori infection group and the control group regarding inflammation and activity (χ2=165.43, 354.88, P all <.01), respectively.

Statistical differences were also identified in the proportion of three groups in Operative Link for Gastritis Assessment (OLGA) staging (χ2=67.99, P all <.01). In comparison with type II H pylori infection group and the control group, the level of pepsinogen I, pepsinogen II, and gastrin17 increased in the type I H pylori infection group and serum pepsinogen (PG) I/PG II ratio (PG I/PG II ratio) decreased (χ2=35.08, 166.24, 134.21, 141.19; P all <.01), respectively.

Researchers determined the severity of gastric mucosal inflammation and activity were worsened by Type I H pylori infection. Additionally, H pylori infection was prone to induce atrophy of gastric mucosa, while type I H pylori infection played a significant role in advancing the progress of atrophic gastritis and affected the level of serum gastric function.

The study authors concluded, “Different types of H pylori had different characteristics.” They added, “The clinical application of H pylori eradication should be differentiated based on the H pylori antibody typing classification and individualizing eradication of H pylori can benefit more people.”


Liu W, Tian J, Hui W, et al. A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis. Sci Rep. Published online February 18, 2021. doi.org/10.1038/s41598-021-83647-6