Resistance to Immune Checkpoint Inhibition in Pancreatic Cancer
Research presented at SITC 2019 looks at 2 different mechanisms for resistance to immune checkpoint inhibition in pancreatic ductal adenocarcinoma.
Pancreatic Disorders
PANCREATIC DISORDERS
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Development of Validated Method to Assess, Characterize Pain Mechanisms in Chronic Pancreatitis
Pain phenotypes can be used in the future to attempt prediction of response to treatment in patients with painful chronic pancreatitis and thus provides a framework for personalized pain management.
Effects of Surgeon Volume, Nurse-to-Patient Ratio on Potential Complications With Pancreaticoduodenectomy
Although higher nurse-to-patient ratios ensure good outcomes for patients undergoing pancreaticoduodenectomy, PD-specific surgeon volume has a greater effect on risks of complications for these patients.
Gene Fusions Found in Pancreatic, Biliary IOPNs
Patterns of genetic alterations could guide management.
PERT Led to Insignificant Body Weight Increase in Those With PEI
Pancreatic enzyme replacement therapy (PERT) increased body weight of individuals with pancreatic exocrine insufficiency (PEI) following pancreatoduodenectomy as compared with placebo; however, the effect was not significant.
FCSEMS May Be an Effective First-Line Treatment for Chronic Pancreatitis-Associated BBSs
The study researchers concluded that endoscopic biliary drainage with temporary FCSEMS placement be considered a first-line therapy for CP-associated BBS, and that surgery should still be considered in patients who fail stricture resolution following 1 year indwell.
Childhood Episode of Pancreatitis May Increase Risk for Diabetes Later
A history of a clinically resolved, single event of acute pancreatitis in childhood is associated with an increased risk for diabetes during young adulthood.
Acute Pancreatitis in Childhood May Increase Risk for Type 2 Diabetes
Patients with a history of acute pancreatitis may require closer follow-up and control of diabetes risk factors in young adulthood.
Diverse Risk Factors Associated With Calcifications in Chronic Pancreatitis
Pancreatic calcifications are associated with diverse etiological risk factors in patients with chronic pancreatitis (CP), attesting to the complexity of CP as a disease, and possibly having implications for disease classification.
No Association Between Antihypertensive Drugs and Pancreatic Cancer Risk
The study did not observe any clinically relevant association between use of antihypertensive drugs and pancreatic cancer risk in patients with chronic pancreatitis.
Antithyroid Drugs and Risk for Acute Pancreatitis: Is There a Link?
Based on a case-crossover analysis, there was an increased risk for acute pancreatitis associated with ongoing methimazole/carbimazole or propylthiouracil treatment.
Necrotizing Pancreatitis: Colonic and Pleural Involvement
The study highlights the complexity of patients with necrotizing pancreatitis and the importance of early recognition of possible complications colonic and pleural complications.
Advanced ML Superior to TNM Staging in Predicting Pancreatic Cancer Survival
Traditional prognostic evaluation methods, ie, TNM staging, do not incorporate certain clinical and socioeconomic factors that impact patient survival.
Pancreatitis: Acute Recurrent Pancreatitis and Pain Modulatory Phenotypes
This study highlights a unique way to assess abdominal pain in patients with chronic pancreatitis; however, the practicality, both for the patient and the physician, may be challenging to incorporate into routine practice.
Acute Pancreatitis Linked to Black Elderberry Extract
Black elderberry extract could potentially induce pancreatitis, as described in a recent case report published in the journal Digestive Diseases and Sciences.
Guidelines for the Diagnosis and Management of Pancreatic Cystic Neoplasms
Based on the latest developments in diagnostic modalities and a review of current guidelines, including the AGA, The IAP, and the European Study Group on Cystic Tumors of the Pancreas (European), this report discussed recommendations for the diagnosis and management of pancreatic cystic neoplasms (PCN).
Antifibrotic Therapy for Chronic Pancreatitis Gets Orphan Drug Designation
The Food and Drug Administration (FDA) has granted Orphan Drug designation to TLY012 (Theraly Fibrosis) for the treatment of chronic pancreatitis.
First Oral GLP-1 Receptor Agonist Approved for Type 2 Diabetes
Rybelsus is the first glucagon-like peptide (GLP-1) available in a tablet formulation that is approved for once daily use.
AGA Clinical Practice Update Reviews Pancreatic Necrosis Patient Care
The researchers discussed the necessity of using a multidisciplinary approach, utilizing a specialized referral center with nutritionists, medical intensivists, procedural radiologists, advanced endoscopists, and pancreatic surgeons who have expertise treating patients with pancreatic necrosis in a multidisciplinary manner.
ASTRO Issues Guideline for Radiation Treatment in Pancreatic Cancer
In a new American Society for Radiation Oncology clinical practice guideline, recommendations are presented for radiation treatment of pancreatic cancer.
Linagliptin Noninferior for CV Risk in Early Type 2 Diabetes
Linagliptin is noninferior to glimepiride for adults with relatively early type 2 diabetes and elevated cardiovascular risk.
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