Futility Concerns Halt C difficile Vaccine Trial
The efficacy, immunogenicity, and safety of a Clostridioides difficile toxoid vaccine candidate was assessed.
Other Bowel Disorders
OTHER BOWEL DISORDERS
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Senna or Magnesium Oxide Relieves Chronic Idiopathic Constipation Symptoms
This randomized, placebo-controlled trial compared the safety and efficacy of senna, a stimulant laxative, vs magnesium oxide, an osmotic agent, to treat chronic idiopathic constipation.
Digital Manometry Device May Be Effective for Evaluating Anorectal Function in Patients With Constipation
Digital manometry provides similar pressure readings compared with the gold-standard high-resolution anorectal manometry in patients with chronic constipation and fecal incontinence.
Diet Modifications Decrease Intestinal Inflammation in Patients With Diverticulitis
While the etiopathogenesis of diverticulitis is not completely understood, recent evidence suggests that chronic inflammation and alterations in the gut microbiome may be key factors in the development of diverticulitis.
Multidisciplinary Care Improves Symptoms Best in Functional GI Disorders
Researchers compared integrated multidisciplinary clinical care vs gastroenterologist-only care with regard to symptoms, specific functional disorders, psychological state, quality of life, and cost of care for treating functional gastrointestinal disorders.
Low-Dose Zinc Therapy Effective for Treating Diarrhea Among Young Children
The goal of this study was to see if a lower dosage of zinc than 20 mg/d could decrease acute diarrhea in young children without increasing vomiting.
Crohn Disease: Steroid IV Therapy Boosts Risk for Short Bowel Syndrome
Researchers analyzed independent risk factors for short bowel syndrome in patients with Crohn disease in an effort to develop preventive strategies.
Dabrafenib and Trametinib Show Promise in Advanced Cholangiocarcinoma
Phase 2 clinical trial shows promising result for dabrafenib and trametinib combination in patients with advanced cholangiocarcinoma with a BRAFV600E mutation.
Case Study: Pain in the Right Lower Abdomen
A young woman presents to the emergency department with right lower quadrant pain that has become progressively worse over the past 18 hours.
Celiac Disease: Is There a Link With Environmental Chemicals and Metals?
A team of researchers recently evaluated serum concentrations of persistent organic pollutants to determine how they may affect celiac disease.
Poor Diagnostic Power of Functional Bowel Disorders With Colonoscopy
Investigators examined the diagnostic yield of colonoscopies for patients with functional bowel disorders without alarm features.
Does a Gluten-Free Diet Change Intestinal Microbiota in Pediatric Celiac Disease?
It is unclear if alterations in the intestinal microbiota cause celiac disease, or if the changes are a result of celiac disease.
Case Study: Epigastric Abdominal Pain and Vomiting
A patient presents to the emergency department with intermittent epigastric abdominal pain that radiates into his back.
Pediatric Fecal Viral Shedding Examined as Route of COVID-19 Transmission
Although children appear to be at low risk for COVID-19, data suggests that prolonged fecal viral shedding may position children as potential carriers of the virus.
Bowel Procedure During Ovarian Surgery Linked to Higher Odds of Surgical Infection
The odds of developing a surgical infection after cytoreductive surgery for ovarian cancer more than doubled in women who had bowel resection or repair.
High-Risk Regions for Childhood Diarrheal Mortality
Childhood mortality due to diarrhea remains high in some regions due to a combination of child growth failure, poor water, sanitation, and hygiene, and low oral rehydration therapy coverage.
Effects of a Gluten-Free Diet in Patients With Type 1 Diabetes and Asymptomatic Celiac Disease
In individuals with type 1 diabetes who test positive for asymptomatic celiac disease, a gluten-free diet may increase postprandial glycemic levels.
Diarrheagenic E coli Increases Risk for Reactive Arthritis and Musculoskeletal Symptoms Among Travelers
Researchers evaluated the association between diarrheagenic E coli and development of reactive arthritis and musculoskeletal symptoms among international travelers.
Length of Hospital Stay Unaffected by Antibiotic Omission in Uncomplicated Diverticulitis
For patients with uncomplicated acute diverticulitis, forgoing antibiotic use did not increase the length of hospital stay.
COVID-19: Symptoms and Laboratory Findings Gastroenterologists Need to Know
Although patients with COVID-19 are known to present with constitutional and respiratory symptoms such as fever, cough, sore throat, and shortness of breath, there is growing evidence that these patients can also experience significant gastrointestinal symptoms such as nausea, vomiting, and diarrhea.
Low Rate of Colorectal Cancer Detected After Episode of Acute Diverticulitis
The prevalence of diverticulosis has been increasing, and research has demonstrated an increased risk of underlying colorectal cancer in this population.
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