Lactobacillus Supplement Metabolic Effects in Patients With Overweight, Obesity

Taking probiotics linked to weight loss.
Taking probiotics linked to weight loss.
Researchers determined if Lactobacillus supplementation can improve metabolic parameters to prevent disease in patients who are overweight or obese.

Lactobacillus supplements can reduce low-density lipoprotein cholesterol (LDL-C) and total cholesterol in patients who are overweight or obese, according to study findings published in Clinical Nutrition.

Researchers conducted a systematic review and meta-analysis across studies in 7 electronic databases and 2 trial registers (; World Health Organization’s International Clinical Trials Registration Platform Search Portal [ICTRP]). A total of 9 randomized controlled trials that assessed the effect of Lactobacillus supplementation in patients who were overweight or obese were identified and included in the analysis.

The study population included adults aged 18 to 65 years who were classified as overweight based on a body mass index (BMI) of 25 to 29.9 or obese, defined as a BMI of 30 or greater. Trials that were conducted in Asian countries included patients with a BMI of greater than 23.

In this study, researchers focused on glycemic and lipid indicators for the primary outcome, such as LDL-C, total cholesterol, fasting plasma glucose, glycated hemoglobin (HbA1c), high density lipoprotein cholesterol (HDL-C), lipoprotein(a), or triglycerides.

Researchers measured the differences in outcomes between the treatment and control group participants using the mean difference (MD). For crossover studies, researchers recorded the mean values at the end of the first-crossover period. Heterogeneity was measured using I2, with an I2 of greater than 50% indicating significant heterogeneity.

Across the trials, there was no significant effect of Lactobacillus supplementation on fasting plasma glucose (MD, -1.55 mg/dL; 95% CI, -3.68 to 0.57; P =.15; I2=62%). However, analysis of a subgroup based on study duration revealed that there was significant reduction in fasting plasma glucose only after 12 weeks of supplementation (MD, -1.81 mg/dL; 95% CI, -3.08 to -0.54; P =.005; I2=1%).

Lactobacillus supplementation did have a significant effect on LDL-C (MD, -5.27 mg/dL; 95% CI, -8.28 to -2.25; P =.0006; I2=0%) and total cholesterol (MD, -4.84 mg/dL; 95% CI, -8.29 to -1.39; P =.006; I2=0%).

No significant effect on HDL-C (MD, -0.86 mg/dL; 95% CI, -1.86 to 0.13; P =.09; I2=0%) or triglycerides (MD, -6.82 mg/dL; 95% CI, -14.07 to 0.43; P =.07; I2=1%) was observed.

While Lactobacillus supplementation did not have a significant effect on systolic blood pressure (BP) (MD, -2.03 mm Hg; 95% CI, -4.07 to 0.01; P =.05; I2=28%), it did have some short-term effect on diastolic BP (MD, -2.68 mm Hg; 95% CI, -4.73 to -0.64; P =.01, I2=67%).

With only a few studies included, researchers were unable to conduct sensitivity and subgroup analysis to assess heterogeneity and publication bias within studies.

Overall, patients who took Lactobacillus supplements observed reduction in LDL-C, total cholesterol, fasting plasma glucose after 12 weeks of supplementation, and BP (short-term), but no significant effects on HDL-C or triglycerides.

Lactobacillus supplementation represents a promising approach in the management of obesity-related diseases,” the study authors concluded.


Qiu X, Wu Q, Li W, Tang K, Zhang J. Effects of lactobacillus supplementation on glycemic and lipid indices in overweight or obese adults: A systematic review and meta-analysis. Clinical Nutrition. 2022;41(8):1787-1797. doi:10.1016/j.clnu.2022.06.030