Microbiome

Latest News

Suboptimal Vaginal Microbiota After Chlamydia trachomatis Treatment

By

Bradley van Paridon

Data on the composition and structure of the vaginal microbiome in women with genital Chlamydia trachomatis published in The Journal of Infectious Diseases revealed that Lactobacillus iners- dominated communities were most common post-treatment.

Low-FODMAP Diet in Inflammatory Bowel Disease

By

Lauren Dembeck, PhD

The abundance of particular gut microbes believed to regulate immune response were reduced in fecal samples from participants on the low-FODMAP diet compared with those on the control diet.

Immigration to the United States Associated With Increased Antibiotic Resistance Genes

By

Bradley van Paridon

In women from 2 independent ethnic groups relocating from Thailand to the United States, investigators found a rapid increase in gut microbiome antibiotic resistance genes richness and abundance.

Incidence of Bloodstream Infections Lower in Recurrent CDI With Fecal Transplant

By

Sweta Gupta

Patients with recurrent Clostridioides difficile infection (CDI) were less likely to develop bloodstream infections (BSI) if treated with fecal microbiota transplantation (FMT) compared with antibiotics.

No Distinct Microbiome Profile for IBS in Swedish Population

By

Lauren Dembeck, PhD

The researchers concluded that this is the first study to investigate the mucosa-associated gut microbiome in an adult population-based cohort and that no distinct microbial signature was observed in IBS.

Changes in Gut Microbiome Associated With Biologic Therapy in IBD

By

Lauren Dembeck, PhD

Prospective studies are needed to determine what changes are significantly associated with treatment, whether these changes are causes or effects of response, and whether the composition of the intestinal microbiome can be used to select treatments for patients with IBD.

The Role of Gut Microbiome in Inflammatory and Allergic Skin Diseases

By

Brandon May

This review gives insight into the role of gut microbiome alterations in the pathogenesis of psoriasis, acne, rosacea, hidradenitis suppurativa, and atopic dermatitis.

Microbiome Alterations Vary With Infections, Disease State

By

Zahra Masoud

Three studies investigated and assessed changes in the gut microbiome among recipients of liver transplant, patients with hepatitis C virus, and patients with primary sclerosing cholangitis.

Improved Cognition Linked to Changes in Microbiota After Fecal Transplant in Hepatic Encephalopathy

By

Sweta Gupta

Beneficial changes in microbial composition and functionality with capsular fecal microbiota transplant lead to improved cognition in patients with cirrhosis and recurrent hepatic encephalopathy.

Consensus Report Outlines General Organization, Criteria to Establish a Stool Bank

By

Gastroenterology Advisor Contributing Writer

Stool banks may guarantee reliable, timely and equitable access to fecal microbiota transplantation for patients and a traceable workflow that ensures safety and quality of procedures.

Fecal Microbiota Transplant Cuts Bloodstream Infection in Clostridioides difficile

Patients with recurrent Clostridioides difficile infection (CDI) who receive treatment with fecal microbiota transplantation (FMT) are less likely to develop a primary bloodstream infection (BSI) than those receiving antibiotics.

Lower Simvastatin Dose Preferred in Treatment of Decompensated Cirrhosis

By

Gastroenterology Advisor Contributing Writer

As a part of the LIVERHOPE project, researchers evaluated the safety of 2 different simvastatin doses in combination with rifaximin vs placebo in patients with decompensated cirrhosis.

Infant Birth, Rearing Affects Gut Microbiome and Metabolic Health in Monkeys

By

Gastroenterology Advisor Contributing Writer

Among rhesus macaques, mother-reared infants more quickly acquired adult-typical microbiota and had higher levels of beneficial commensal taxa compared with Cesarean-delivered, human-reared, formula-fed infants.

RWE Supports Gut Microbiota as an Independent Driver of Response to ICIs in Lung Cancer, Melanoma

By

Susan Moench, PhD, PA-C

Antibiotic therapy administered prior to treatment with ICIs was negatively associated with OS across tumor types, as well as tumor response, the researchers noted.

Fecal Microbiota Transplant in the Treatment of Obesity

By

Michelle Petropoulos, DMSc, PA-C, DFAAPA

The human gut microbiota has been identified as a metabolic organ having a significant effect on host metabolism.

Association Between Oral Antibiotics and Risk for Colorectal Cancers: A Matched Case-Control Study

By

Gastroenterology Advisor Contributing Writer

The researchers concluded that the use of oral antibiotics was associated with colorectal cancer, but the effect size and pattern of risk varied by anatomical location in the colorectum.

New Link Between Altered Microbiota and Cognitive Performance

By

Alyssa Capel

Cirrhosis and chronic liver disease are endemic in the veteran population. These conditions — often associated with alcohol and substance use or obesity — can be exacer-bated by posttraumatic stress disorder (PTSD). In turn, PTSD is often linked with great-er mortality from chronic liver disease.

Baby Biome Project Indicates Newborn Microbiota Affected by Delivery Method

By

Dibash Kumar Das, PhD

The researchers discovered that while babies delivered vaginally received most of their gut bacteria from their mothers, babies delivered by cesarean birth did not. In addition, babies delivered by cesarean harbored more bacteria commonly associated with hospital.

Investigational Lactose Intolerance Therapy Misses End Points in Phase 3 Trial

By

Brian Park, PharmD

Ritter Pharmaceuticals announced that the phase 3 clinical trial of RP-G28 for lactose intolerance did not meet its primary or secondary end points.

HLA Alleles With Risk for AS, RA Affect Gut Microbiome

By

Hannah Dellabella

Researchers examined the effects of HLA-B27 and HLA-DRB1 alleles on the intestinal microbiome of healthy individuals.