Irritable Bowel Syndrome (IBS)
IRRITABLE BOWEL SYNDROME (IBS)
Feature Article
AGA Recommendations for Evaluation of Functional Diarrhea and Diarrhea-Predominant IBS in Adults
Based on technical review and expert consensus, a guideline committee put together by the American Gastroenterological Association (AGA) released official recommendations on the laboratory evaluation of functional diarrhea and diarrhea-predominant irritable bowel syndrome (IBS-D) in immunocompetent adults. This report was published in Gastroenterology. Members of the AGA guideline committee and authors of the technical review…
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Challenges, Controversies in Drug Safety Monitoring
The FDA plays a critical role in the evaluation of drug safety prior to approval and following introduction into clinical practice.
No Distinct Microbiome Profile for IBS in Swedish Population
The researchers concluded that this is the first study to investigate the mucosa-associated gut microbiome in an adult population-based cohort and that no distinct microbial signature was observed in IBS.
Effects of Human Milk Oligosaccharides on Gastrointestinal Symptoms in IBS: Q&A With Dr Magnus Simrén
Oral supplementation with 2 unique forms of human milk oligosaccharides can provide nutritional support that significantly reduces abnormal stool consistency, abdominal pain, and bloating and improves health-related quality of life in patients with IBS of all subtypes.
Zinc Deficiency May Perpetuate Irritable Bowel Syndrome Pathology/Symptoms
Zinc deficiency may perpetuate the underlying pathophysiology of IBS as well as associated psychiatric conditions, via the role zinc plays in the “brain-gut” axis, the immune system, and gastrointestinal barrier integrity.
Rifaximin and Meaningful Pain Improvement in IBS With Diarrhea
Rifaximin treatment resulted in meaningful pain improvements of abdominal pain in a high percentage of patients, irrespective of baseline severity category and treatment course.
Expert Q&A: Low-FODMAP Diet Risky in Patients With Eating Disorders
In individuals with IBS, screening for an eating disorder or maladaptive eating is recommended prior to recommending the low-FODMAP diet.
Cognitive Therapy by Phone, Web May Ease Irritable Bowel Symptoms
Cognitive behavioral therapy (CBT) delivered via telephone and web is effective for relieving the symptoms of irritable bowel syndrome.
Risk for Developing Idiopathic Pulmonary Fibrosis Increased in IBD
Patients with inflammatory bowel disease (IBD), especially male patients, have an increased risk for development of idiopathic pulmonary fibrosis.
Eluxadoline Treatment Safe, Effective in IBS-D With Failed Loperamide Therapy
This study prospective validates previous findings revealing eluxadoline to be a safe, effective IBS-D treatment in patients reporting inadequate symptom relief with prior loperamide use.
FDA Approves First-in-Class Treatment for IBS-C
The Food and Drug Administration (FDA) has approved Ibsrela (tenapanor; Ardelyx) for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults.
Eluxadoline: Efficacy and Safety for Irritable Bowel Syndrome With Diarrhea
Eluxadoline appears to be a safe and effective treatment for the symptoms of irritable bowel syndrome with diarrhea (IBS-D) in patients with intact gallbladders who have previously reported inadequate relief with loperamide.
Low FODMAP Diet in Irritable Bowel Syndrome: Controversies and Practicality
Further studies will need to look at different subtypes of IBS (IBS-diarrhea, IBS-constipation, IBS-mixed) and improved breath testing, as well as evaluating underlying gut microbiome profiles and how they may affect a response to a low FODMAP diet.
Irritable Bowel Syndrome and Vitamin D: Is There a Connection?
Low vitamin D levels have been linked to multiple diseases including some cancers, neurologic disorders, decrease in bone density, and cognitive decline in the elderly, and research suggests that a possible inflammatory response in the gut when vitamin D levels are low may cause irritable bowel syndrome.
Time-Saving Benefits of Point-of-Care Ultrasonography for Small Bowel Obstruction
Compared with computed tomographic (CT) scan, point-of-care ultrasonography has demonstrated high accuracy in diagnosing small bowel obstruction in the emergency department, which may result in a significantly shorter time to diagnosis.
AGA Issues Guidelines for Laboratory Evaluation of Functional Diarrhea, IBS-D
Recommendations aim to help clinicians in choosing appropriate laboratory tests to exclude other diagnoses in the setting of suspected functional diarrhea or diarrhea-predominant irritable bowel syndrome.
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