Based on technical review and expert consensus, a guideline committee put together by the American Gastroenterological Association (AGA) released official recommendations on the laboratory evaluation of functional diarrhea and diarrhea-predominant irritable bowel syndrome (IBS-D) in immunocompetent adults. This report was published in Gastroenterology. Members of the AGA guideline committee and authors of the technical review…
The researchers concluded that this is the first study to investigate the mucosa-associated gut microbiome in an adult population-based cohort and that no distinct microbial signature was observed in IBS.
Oral supplementation with 2 unique forms of human milk oligosaccharides can provide nutritional support that significantly reduces abnormal stool consistency, abdominal pain, and bloating and improves health-related quality of life in patients with IBS of all subtypes.
Zinc deficiency may perpetuate the underlying pathophysiology of IBS as well as associated psychiatric conditions, via the role zinc plays in the “brain-gut” axis, the immune system, and gastrointestinal barrier integrity.
Eluxadoline appears to be a safe and effective treatment for the symptoms of irritable bowel syndrome with diarrhea (IBS-D) in patients with intact gallbladders who have previously reported inadequate relief with loperamide.
Further studies will need to look at different subtypes of IBS (IBS-diarrhea, IBS-constipation, IBS-mixed) and improved breath testing, as well as evaluating underlying gut microbiome profiles and how they may affect a response to a low FODMAP diet.
Low vitamin D levels have been linked to multiple diseases including some cancers, neurologic disorders, decrease in bone density, and cognitive decline in the elderly, and research suggests that a possible inflammatory response in the gut when vitamin D levels are low may cause irritable bowel syndrome.
Compared with computed tomographic (CT) scan, point-of-care ultrasonography has demonstrated high accuracy in diagnosing small bowel obstruction in the emergency department, which may result in a significantly shorter time to diagnosis.
Recommendations aim to help clinicians in choosing appropriate laboratory tests to exclude other diagnoses in the setting of suspected functional diarrhea or diarrhea-predominant irritable bowel syndrome.