Inflammatory bowel disease (IBD)-Disk is a simplified adaptation of the IBD-Disability Index (IBD-DI). According to results from a large cohort validation study, IBD-Disk was found to be both viable and reliable. These findings were published in the Journal of Crohn’s and Colitis.

Researchers assessed 265 patients using both IBD-Disk and IBD-DI at 3- to 12-month intervals at 3 university-affiliated hospitals in France between 2018 and 2019. The participants comprised 194 patients with Crohn’s disease (CD), 70 with ulcerative colitis (UC), and 1 patient with undefined IBD. The researchers measured validity, reproducibility, and consistency of each index and compared these measures with clinical features of the patients.

The researchers observed a strong correlation between IBD-Disk and IBD-DI (r=0.75; P <.001). The internal consistency was reported as a Cronbach α of 0.89 and the reproducibility by an intra-class correlation coefficient of 0.90.


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The researchers reported no bias with respect to IBD type. After correcting for type I errors, significant correlations with IBD-Disk results were reported for: female gender (P <.001); physician global assessment (P <.001); Harvey-Bradshaw index in patients with CD (P <.001); and Mayo sub-score in patients with UC (P <.001).

Overall, features that were observed in patients with higher disability included extra-intestinal manifestations, a history of resection, disease activity based on C-reactive protein, and fecal calprotectin levels among all patients, stricturing behavior in patients with CD, and recent disease onset in patients with UC. However, none of these features remained significant after Bonferroni correction. The highest scoring categories, indicating an increase in disability, were energy, sleep, and anxiety.

A limitation of this study is that no data on psychiatric disorders or somatic comorbidities were collected. While these data might not have been associated with IBD, these conditions could certainly affect the daily lives of patients and contribute to disability.

The study authors concluded that IBD-Disk, while being a simplified version of IBD-DI, was nonetheless an effective and reliable tool in assessing disability in patients with IBD.

Reference

Catherine L B, Mathurin F, Guillaume B, et al. VALIDation of the IBD-Disk instrument for assessing disability in inflammatory bowel diseases in a French cohort: the VALIDate study. [available online May 17, 2020]. J Crohns Colitis. doi:10.1093/ecco-jcc/jjaa100/5838423