Crohn disease and ulcerative colitis comprise the 2 primary subtypes of inflammatory bowel diseases (IBD). IBD currently has no known cure and whose pathogenesis is not well understood. However, an increasing amount of research points to genetic risk factors combined with antibiotic use and changes in intestinal microbiota as triggers for the onset of IBD.1,2…
Pollution of aqueous, terrestrial, and airborne environments by microplastic particles is increasing, and their presence in foods and drinking water has recently been reported. Often, these particles are unintentionally ingested and are present in human stool samples, according to a study published in Annals of Internal Medicine.
MAGNIFI-CD has improved operating characteristics compared to other indices assessing MRI scans of perianal fistula activity in CD, and that the new index may be useful as an outcome measure in clinical trials investigating treatment for perianal fistulizing CD.
The risk for type 2 diabetes was significantly higher for patients who received a diagnosis of IBD from 2003 through 2014 versus those diagnosed from 1977 through 1988 or from 1989 through 2002 (SIRs, 1.79 versus 1.47 and 1.48, respectively).
In terms of benefit and risk, biologics were both considered more beneficial and riskier than immunomodulators. Bowel resection was considered to be slightly more risky, but more beneficial than biologic treatment.
Vedolizumab has demonstrated efficacy among individuals with moderate to severe active Crohn disease, according to a study recently published in Gastroenterology. Improvements were observed in radiologic, histologic, and endoscopic outcomes. This open-label, phase-3b trial (VERSIFY; ClinicalTrials.gov identifier: NCT02425111) included 101 individuals who had experienced active Crohn disease for 3 months or more between March 2015…
An update to the American College of Gastroenterology guideline may promote use of more precise diagnostic tools and evidence-based treatments and may enhance health outcomes for patients with Crohn disease.