Inflammatory Bowel Diseases (IBD)

Latest News

Microscopic Colitis: New PPI Data

By

C. Andrew Kistler, MD, PharmD

The exact pathophysiology of microscopic colitis is not completely understood, though PPIs and NSAIDs are 2 medications commonly implicated for triggering the inflammatory process.

Vedolizumab Shows Better Safety Profile Compared With Anti-Tumor Necrosis Factor-α in IBD

By

Vincent Soreca

Researchers compared the clinical effectiveness and safety profiles of vedolizumab and anti-TNFα agents in biologic-naïve adult patients with ulcerative colitis and Crohn disease.

Steroid Use, Presence of Central Venous Catheter Predict VTE Risk in Children With IBD

By

Brandon May

Investigators examined the clinical characteristics of patients with IBD and VTE and identified risk factors associated with VTE occurrence.

Clinical Remission Observed With Ozanimod in Ulcerative Colitis Trial

By

Brian Park, PharmD

Positive topline results were announced from the phase 3 True North trial evaluating the efficacy of ozanimod as an induction and maintenance therapy for adults with moderate to severe ulcerative colitis.

Risk for Adverse Events Not Increased After COVID-19 Vaccine in IBD

Individuals with inflammatory bowel disease (IBD) do not have an increased risk for adverse events (AEs) after the mRNA COVID-19 vaccination.

Serological Responses Support COVID-19 Vaccine Recommendations in Patients With IBD

By

Colby Stong

Investigators evaluated serological responses to COVID-19 vaccines in patients with irritable bowel disease.

Frequency of Tofacitinib-Linked Malignancy Events in Ulcerative Colitis

By

Rita Aghjayan

Researchers analyzed malignancy events and their relationship to tofacitinib treatment levels in patients with ulcerative colitis.

Addressing the “Therapeutic Ceiling” in Drug Discovery for Ulcerative Colitis

By

Emily Pond

Reviewers addressed potential reasons for the shortcomings of newer therapies and proposed solutions to increase treatment efficacy in ulcerative colitis.

Diets Compared for Mild-to-Moderate Crohn Disease in Adults

The specific carbohydrate diet is not superior to the Mediterranean diet for the remission of symptoms in adults with mild-to-moderate Crohn disease.

Fecal Microbiota Transplant Improves Ulcerative Colitis Indices in Pediatric Patients

By

Brandon May

Investigators conducted a randomized controlled trial to assess the use of fecal microbiota transplants in children with ulcerative colitis.

Efficacy and Safety of Tofacitinib Re-Treatment for Ulcerative Colitis

By

Virginia A. Schad, PharmD, RPh

Investigators examined the safety and efficacy of tofacitinib re-treatment in patients with ulcerative colitis who underwent treatment interruption.

AGA Issues Recommendations for Moderate-to-Severe Crohn Disease

In clinical practice guidelines from the American Gastroenterological Association (AGA) published in the June 1 issue of Gastroenterology, recommendations are presented for the management of moderate-to-severe luminal and fistulizing Crohn disease (CD) in adult outpatients.

Patients With Ulcerative Colitis in Remission Who Continue Infliximab Have Significantly Higher Remission Rates

By

Colby Stong

Researchers compared outcomes and remission rates among patients with ulcerative colitis who continue or discontinue treatment with infliximab.

Zeposia Approved for Moderately to Severely Active Ulcerative Colitis

By

Diana Ernst, RPh

The FDA has approved Zeposia® (ozanimod) for moderately to severely active ulcerative colitis in adults.

Low FODMAP Diet and IBD: A Potential Option?

By

C. Andrew Kistler, MD, PharmD

Current research indicates that short-term utilization of an LFD may help ameliorate some mild IBS symptoms associated with quiescent IBD, while further long term studies are still needed.

Inflammatory Bowel Disease and Inflammatory Dermatologic Condition Comorbidities: A Distinct Subgroup of IBD Patients

By

Jessica Nye, PhD

Researchers evaluated the prevalence and severity of dermatologic inflammatory conditions in patients with IBD.

Novel Probiotic Combination for the Treatment of Crohn Disease

By

Emily Pond

Investigators analyzed the effects of a novel probiotic supplement on Crohn disease-like ileitis in murine models.

Ozanimod Maintenance in Patients With Ulcerative Colitis Associated With Corticosteroid-Free Remission

By

Bradley van Paridon

Researchers analyzed the rates of achieving corticosteroid-free remission in patients with ulcerative colitis receiving maintenance treatment with ozanimod vs placebo.

Tofacitinib for the Long-Term Maintenance of Remission in Ulcerative Colitis

By

Emily Pond

Researchers aimed to determine the safety and efficacy of tofacitinib in maintaining remission from ulcerative colitis over long-term follow up.

Vedolizumab Therapy More Effective in Certain Crohn Disease Subpopulations

By

Kate Shanaghan

Investigators aimed to identify subpopulations of patients with Crohn Disease in whom vedolizumab had greater success at achieving clinical remission than anti-TNFα.