Inflammatory Bowel Diseases (IBD)
Inflammatory Bowel Diseases
Feature Article
Exclusive Enteral Nutrition Significantly Alters Gut Microbiota in IBD
Crohn disease and ulcerative colitis comprise the 2 primary subtypes of inflammatory bowel diseases (IBD). IBD currently has no known cure and whose pathogenesis is not well understood. However, an increasing amount of research points to genetic risk factors combined with antibiotic use and changes in intestinal microbiota as triggers for the onset of IBD.1,2…
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Etrasimod in Ulcerative Colitis: Promising Phase 2 Results
Researchers evaluated the efficacy and safety of etrasimod, an oral, selective sphingosine 1-phosphate receptor modulator in development for immune-mediated inflammatory disorders, in patients with moderate to severe ulcerative colitis.
High Prevalence of Endoscopic, Histologic Activity in Clinically Quiescent UC
A high prevalence of endoscopic and histologic disease activity was found in clinically quiescent ulcerative colitis.
Novel Serum Biomarker Panel Predicts Crohn Disease Diagnosis
A panel of serum biomarkers was found to identify patients who will develop Crohn disease up to 5 years before diagnosis.
Is the Progression of Elderly-Onset IBD the Same as Adult-Onset IBD?
Risks of surgery, hospitalization, and corticosteroid exposure in elderly-onset IBD was similar to those in adult-onset IBD, whereas immunomodulators and biologic agents were used less frequently.
Case Report: Autoimmune Encephalitis in Comorbid Crohn Disease and Ankylosing Spondylitis
In this case study presented at ACTRIMS 2020, researchers reported on data from a patient with Crohn disease and ankylosing spondylitis who developed autoimmune encephalitis while receiving infliximab.
Upadacitinib Is Safe and Efficacious in Patients With Active Ulcerative Colitis
Upadacitinib was effective in inducing remission in patients with moderate to severe ulcerative colitis.
Frailty Increased in Patients With IBD After Immunosuppression
As frailty has been linked to outcomes in patients with other inflammatory diseases, the researchers examined the relationship between frailty and the risk for infections after immunosuppression for inflammatory bowel disease.
Long-Term Follow-Up Reveals Positive Patient Outcomes After Surgical Treatment of Ulcerative Colitis
Ileal pouch–anal anastomosis surgery as treatment for ulcerative colitis met the expectations of cure of the disease, maintaining adequate long-term intestinal functionality associated with a good quality of life.
The Efficacy of Tofacitinib and Other JAK Inhibitors in Ulcerative Colitis
Tofacitinib is the first JAK inhibitor approved by the FDA for the treatment of UC in patients whose disease worsened or did not improve with conventional therapy.
Patients With Ulcerative Colitis May Be at Risk for Lower Bone Mineral Density
A potential association was found between ulcerative colitis and decreased bone mineral density, regardless of steroid exposure.
Adolescent IBD: Medication and General Health Management Considerations
This review examines the unique manifestations of inflammatory bowel disease (such as growth and pubertal delay), health maintenance issues, and treatment considerations in the adolescent.
Neutrophil-Related Serum Markers Accurately Detect Mucosal Healing in Ulcerative Colitis
Prospective studies are needed to validate the Ulcerative Colitis Response Index algorithm as a surrogate marker panel for mucosal healing, with the ultimate goal being to avoid unnecessary endoscopic evaluations.
Guidance Issued for Food Intake in Inflammatory Bowel Disease
There is insufficient evidence for recommending specific changes or restrictions of intake of fruit and vegetables in ulcerative colitis.
Pain in IBD Associated With Cognitive and Behavioral Factors
Emotions, cognitions, and behaviors are significantly associated with pain severity and pain-related interference in IBD, including pain-specific cognitions and behaviors.
General Dysfunctional Thinking Worsens Anxiety, Depression in IBD
The study examined the importance of confronting general dysfunctional beliefs, particularly notions of low self-efficacy and failure, in short-term therapy for patients with IBD.
Validating Clinical Trial Endpoints in Ulcerative Colitis
Authors examine the current challenges in endpoints of randomized controlled trials and summarize the validity of current endpoints used in patients with ulcerative colitis.
Inflammatory Bowel Disease Is an Independent Risk Factor for Post-Discharge VTE
An inflammatory bowel disease diagnosis conferred an increased risk for venous thromboembolism; however, in surgical patients, ulcerative colitis but not Crohn disease was responsible for the elevated risk.
IBD, Hidradenitis Suppurativa May Be Linked
There appears to be a link between hidradenitis suppurativa and inflammatory bowel disease.
Incidence of Osteoporosis Significantly Higher in IBD
Incidence of osteoporosis is significantly increased in patients with inflammatory bowel disease.
IBD May Increase Chronic Kidney Disease Risk
The risk of CKD in patients with inflammatory bowel disease is highest among young individuals.
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