Inflammatory Bowel Diseases (IBD)
Inflammatory Bowel Diseases
Feature Article
Exclusive Enteral Nutrition Significantly Alters Gut Microbiota in IBD
Crohn disease and ulcerative colitis comprise the 2 primary subtypes of inflammatory bowel diseases (IBD). IBD currently has no known cure and whose pathogenesis is not well understood. However, an increasing amount of research points to genetic risk factors combined with antibiotic use and changes in intestinal microbiota as triggers for the onset of IBD.1,2…
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Risk for Birth Defects Not Increased With Adalimumab
Adalimumab exposure in pregnancy does not increase the risk for birth defects.
Indefinite Dysplasia in IBD is Independently Associated With Advanced Colorectal Neoplasia
In patients with inflammatory bowel diseases (IBD) who underwent colonoscopic surveillance for colorectal neoplasia (CRN), indefinite dysplasia was independently associated with a significant increase in advanced CRN risk.
Fistula Relapse Risk in Perianal Crohn Disease Is Higher After Discontinuation of Anti-TNF
Discontinuation of anti–TNF therapy in patients with perianal Crohn disease may increase the risk for fistula relapse.
Prostate Cancer Risk Higher Among Men With IBD
Men with ulcerative colitis may be particularly at risk for prostate cancer, according to researchers.
Significant Differences in Medication Use Patterns Among Elderly vs Younger Patients With Inflammatory Bowel Disease
Researchers compared patient characteristics, patterns of medication use, and comorbidities among elderly and younger patients with inflammatory bowel disease.
Patients with Ulcerative Colitis and Crohn Disease Demonstrate Increased Risk for Psychiatric Illnesses
For both patients with ulcerative colitis and those with Crohn disease, psychiatric diagnoses were more common in those who were elderly (greater than 65 years old), women, and white, and those with psychiatric conditions more frequently had a history of alcohol abuse, tobacco and substance abuse, personality disorder, and corticosteroid use.
Stelara Approved for Moderately to Severely Active Ulcerative Colitis
The Food and Drug Administration (FDA) has approved Stelara (ustekinumab; Janssen) for the treatment of adult patients with moderately to severely active ulcerative colitis.
Food for Thought: Mood Improvements Following Dietary Modification
A recent report published in the journal Neuropsychobiology describes the case of a 34-year-old woman with major depressive disorder whose symptoms improved following the initiation of an elimination diet.
Hidradenitis Suppurativa Carries Heavy Comorbidity Burden
There is a substantial burden, unawareness, and undertreatment of several systemic comorbidities—particularly cardiovascular and psychiatric—in patients with HS.
Fecal Calprotectin May Be Useful at Predicting IBD Activity in Pregnancy
Researchers concluded that fecal tests like FCP do not appear to be affected by physiological changes that occur during pregnancy and that these tests may be useful in predicting IBD activity across all gestational periods, including conception.
Quality Improvement Program Lowers Prolonged Steroid Use With IBD
A quality improvement program can lower steroid use among patients with inflammatory bowel disease.
Pediatric Care Setting Associated With Better Outcomes in Adolescent IBD
Adolescents with IBD experienced significantly lower steroid and biological use and fewer hospitalizations when treated in a pediatric care setting.
Customizing Electronic Medical Records May Decrease Antimicrobial Usage
Automating the workflow and tracking an antimicrobial stewardship program by customizing electronic medical records may decrease antimicrobial usage.
Risk Factors for Spondyloarthritis in Inflammatory Bowel Disease
Among patients with inflammatory bowel disease (IBD), women, individuals with a history of at least one biological or immunosuppressive therapy, and individuals with Crohn disease are all at an increased risk of developing spondyloarthritis.
Latest Evidence and Clinical Guidance to Reduce Clostridioides difficile Infection Recurrence
Studies present promising therapeutic options to reduce recurrent CDI, as well as strategies to improve favorable economic outcomes.
Low-FODMAP Diet Relieves Gut Symptoms for More IBD Patients
More patients with inflammatory bowel disease following a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols report adequate relief of gut symptoms.
Infection in First Year of Life Increases Later Risk of Developing IBD
Having a mother with a diagnosis of inflammatory bowel disease (IBD), being in the highest socioeconomic quintile at birth, and having an infection in the first year of life increases the risk of developing IBD.
DPP4 Inhibitors Do Not Increase Risk of Inflammatory Bowel Disease
Short-term use of a dipeptidyl peptidase 4 inhibitor (DPP4i) for the treatment of diabetes does not increase the risk of inflammatory bowel disease.
Detection of Fecal Clostridium difficile Toxins of High Importance in Diagnosis
Detection of Clostridioides difficile toxins in fecal matter can lead to accurate diagnosis of C difficile infection.
Analyzing Dietary Therapies for Pediatric Crohn Disease
Researchers conducted a randomized controlled trial to assess tolerability and efficacy of a Crohn disease exclusion diet plus partial enteral nutrition compared with exclusive enteral nutrition.
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