Inflammatory Bowel Diseases (IBD)
Inflammatory Bowel Diseases
Feature Article
Exclusive Enteral Nutrition Significantly Alters Gut Microbiota in IBD
Crohn disease and ulcerative colitis comprise the 2 primary subtypes of inflammatory bowel diseases (IBD). IBD currently has no known cure and whose pathogenesis is not well understood. However, an increasing amount of research points to genetic risk factors combined with antibiotic use and changes in intestinal microbiota as triggers for the onset of IBD.1,2…
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Ingestion of Microplastics Common and Pervasive, Detected in Stool
Pollution of aqueous, terrestrial, and airborne environments by microplastic particles is increasing, and their presence in foods and drinking water has recently been reported. Often, these particles are unintentionally ingested and are present in human stool samples, according to a study published in Annals of Internal Medicine.
New Index Developed For Assessment of Perianal Fistulas in Crohn Disease
MAGNIFI-CD has improved operating characteristics compared to other indices assessing MRI scans of perianal fistula activity in CD, and that the new index may be useful as an outcome measure in clinical trials investigating treatment for perianal fistulizing CD.
Infliximab–TNF Complexes Elicit Anti-Drug Antibody Formation
These findings indicate the importance of optimizing infliximab dosage to a level that achieves efficacy without activating an immune response against the infliximab-TNF complex.
Novel Ulcerative Colitis Treatment Meets Primary End Point of Study
Cobitolimod is a first in class, toll-like receptor 9 (TLR9) agonist with local anti-inflammatory effects in the large intestine, which may promote mucosal healing.
Type 2 Diabetes Risk Increases With Inflammatory Bowel Disease
The risk for type 2 diabetes was significantly higher for patients who received a diagnosis of IBD from 2003 through 2014 versus those diagnosed from 1977 through 1988 or from 1989 through 2002 (SIRs, 1.79 versus 1.47 and 1.48, respectively).
The Link Between Inflammatory Bowel Disease and Depression
The association between disease activity and emotional processing biases may play a role in the higher rates of depression in patients with inflammatory bowel disease.
Childhood-Onset IBD Increases Risk for Psychiatric Morbidity
Risk significantly increased for suicide attempt and mood, anxiety, personality, eating disorders.
Impact of Smoking and Smoking Cessation on Ulcerative Colitis Disease Outcomes
Smoking is not associated with a beneficial impact in disease outcomes in UC. Furthermore, we found no evidence that smoking cessation impacts adversely on subsequent clinical outcomes.
Ulcerative Colitis Outcomes Similar for Smokers, Nonsmokers
No significant difference in rates of flares, thiopurine use, hospitalization for persistent smokers, quitters
Patients Perceive Biologics to Be Among Riskiest Treatments for IBD
In terms of benefit and risk, biologics were both considered more beneficial and riskier than immunomodulators. Bowel resection was considered to be slightly more risky, but more beneficial than biologic treatment.
Association Between Proton Pump Inhibitor Use and Mortality Among US Veterans
Researchers sought to investigate the association between proton pump inhibitor use and cause-specific mortality in US Veterans.
Guidelines Issued for Managing Hidradenitis Suppurativa
Two-part guideline addresses diagnosis, evaluation, management of the chronic inflammatory skin disease
Weight Gain on Infliximab Tied to Sex, Crohn Disease, and Disease Severity
Results provide meaningful information for clinicians to appropriately council patients on expected weight gain after starting infliximab therapy.
Intravenous Vedolizumab Associated With Improved Outcomes in Crohn Disease
Vedolizumab has demonstrated efficacy among individuals with moderate to severe active Crohn disease, according to a study recently published in Gastroenterology. Improvements were observed in radiologic, histologic, and endoscopic outcomes. This open-label, phase-3b trial (VERSIFY; ClinicalTrials.gov identifier: NCT02425111) included 101 individuals who had experienced active Crohn disease for 3 months or more between March 2015…
JAK Inhibitors Evaluated for Crohn Disease, Ulcerative Colitis Treatment
JAK inhibitors effectively induce clinical remission in patients with Crohn disease and clinical and endoscopic remission in patients with ulcerative colitis.
ACG Guideline Update for Managing, Diagnosing Crohn Disease in Adults
An update to the American College of Gastroenterology guideline may promote use of more precise diagnostic tools and evidence-based treatments and may enhance health outcomes for patients with Crohn disease.
Patients on Anti-TNFα for Diseases Other Than IBD May Be at Increased Risk for CD, UC
The aim of this Danish population-based study was to determine the association between anti-TNFα therapy and the risk of developing CD and UC.
ACG Guideline: Ulcerative Colitis in Adults
The American College of Gastroenterology guidelines highlight the preferred practice recommendations to treat adult patients with ulcerative colitis.
Timing Pneumococcal Vaccinations and Immunosuppressive Therapy in IBD
Patients with irritable bowel disease planning to start immunosuppressive therapy may need to receive a pneumococcal vaccination beforehand.
Pediatric Inflammatory Bowel Disease Associated With Increased Risk for Cancer, Mortality
Researchers conducted a retrospective study of pediatric patients with inflammatory bowel disease to estimate the risk for cancer and mortality associated with this diagnosis.
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