Genetic diversity is a hallmark of hepatitis C virus (HCV) in those with chronic infection. Respective HCV genotypes differ by an average of 30%, which contributes to variability in treatment response. This article discusses treatment of chronic HCV infection with oral pan-genotypic combination therapy.
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Crohn disease is a lifelong inflammatory bowel disease with onset at any age, without a cure and requiring lifelong treatment. Among agents investigated for treating Crohn disease, particularly after failure of tumor necrosis factor inhibitors, those targeting interleukin-12, interleukin-23, and T-helper cell-17 pathways have shown clinical efficacy and safety.
Updated August 2021
