HCC Risk Lower With Higher Intake of Vegetable Fats, Polyunsaturated Fats
The source of fats in an individual’s diet may alter the risk of developing hepatocellular carcinoma.
Hepatic Neoplasia
HEPATIC NEOPLASIA
Latest Articles
QoL Extended With Atezolizumab + Bevacizumab in Liver Cancer
For patients with unresectable hepatocellular carcinoma, the combination of atezolizumab and bevacizumab is associated with longer time to deterioration of patient-reported quality of life.
Active Hepatocellular Carcinoma as a Risk Factor for DAA Treatment Failure
Intolerance to treatment with direct acting antiviral treatment was found to be associated with older age and advanced liver disease in patients with hepatocellular carcinoma.
Tumor Size, Stiffness May Be Relevant Biomarkers of Response to ICIs in HCC
The median change in HCC tumor size between responders and nonresponders was statistically significant.
Atezolizumab + Bevacizumab Prolongs Maintenance of QoL vs Sorafenib in Certain Patients With HCC
In this study, deterioration in specific PROs required a drop of at least 10 points from baseline.
Integrating Palliative Care Into Hepatocellular Carcinoma Treatment
The review authors used existing evidence to recommend a new model of palliative care integration in patients with hepatocellular carcinoma.
Prior Exposure to Antibiotics, Antacids Did Not Reduce IO Response in HCC
Researchers hypothesized that because prior studies have demonstrated that common drugs can affect the microbiome, these medications could also impact IO efficacy in HCC.
In Intrahepatic Cholangiocarcinoma, Genomic Profiles of Primary Tumors and Metastatic Lesions Differ
Previous genomic profiling studies have identified potentially targetable alterations in IDH1 and FGFR2 in primary tumor specimens of some patients with IHCC.
PHGDH as a Potential Target in HCC Following Sorafenib Resistance
PHGDH may be a possible target for overcoming sorafenib resistance, preclinical evidence suggests.
Microbiome-Derived Therapy Gets Orphan Drug Status for Hepatocellular Carcinoma
The Food and Drug Administration (FDA) has granted Orphan Drug designation to SFA001 (SFA Therapeutics) for the treatment of hepatocellular carcinoma (HCC).
Level of Hepatitis B Core-Related Antigen and Risk for Hepatocellular Carcinoma
According to a recently published study, a high level of hepatitis B core-related antigen is a complementary risk factor for hepatocellular carcinoma development.
Leisure-Time Physical Activity Linked to Lower Cancer Risk
Leisure-time physical activity at recommended levels is associated with a significantly lower risk for seven cancer types.
Lipophilic Statins Decrease Hepatocellular Carcinoma and Death in Chronic Hepatitis
From a nationwide Swedish registry, researchers found data that showed in patients with hepatitis B or C virus infection, the long-term hepatocellular carcinoma risk was lower in patients who were treated with lipophilic statins.
First Duodenoscope With Disposable Elevator Piece Cleared by FDA
The FDA has cleared the first duodenoscope with a disposable sterile elevator piece, a first in the United States. The design will reduce the number of parts that need to be cleaned and disinfected (reprocessed) between uses.
Investigational Farnesoid X Receptor Agonist Gets Fast Track Status for NASH
The FDA has granted Fast Track designation to TERN-101 (Terns Pharmaceuticals) for the treatment of non-alcoholic steatohepatitis.
Natural History and Tumor Development: Adeno-Associated Virus in the Liver
Study provides a portrait of wild-type AAV infection in the liver with an identification of molecular forms, viral genotypes, viral integrations, and helper virus relationship and with AAV insertions positive selected during HCC development on noncirrhotic liver, which challenges the concept of AAV as nonpathogenic.
When to Use Direct-Acting Antivirals in Hepatocellular Carcinoma
Researchers found data that showed treatment with direct-acting antivirals in patients with hepatocellular carcinoma with advanced cirrhosis improves liver function and could be categorized as safe.
Statins Linked to Lower Risk of Liver Cancer in Patients With HCV, HBV
Lipophilic statins were linked to a lower risk of hepatocellular carcinoma and death in a cohort of patients with chronic hepatitis B/C.
Initial Staging Images for Melanoma Often Show Incidental Findings
The study results provide additional context for clinical interpretation of radiographic evaluations of patients with melanoma and help inform the risk-benefit analysis of staging recommendations.
Phase 3 Trial for Oncolytic Viral Therapy Pexa-Vec Terminated Early
Pexa-Vec, in combination with sorafenib, has failed an interim futility analysis, leading to the early termination of the trial.
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