FDA: Testing Reveals Unacceptable Levels of NDMA in Two H2 Blockers
The FDA has released a summary of the results from tests evaluating ranitidine products for the probable carcinogen N-Nitrosodimethylamine.
Gastroesophageal Reflux Disease (GERD)
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Magnetic Sphincter Augmentation Superior to Proton Pump Inhibitor for Reducing Regurgitation in GERD
Compared with proton pump inhibitor (PPI) therapy, magnetic sphincter augmentation (MSA) was far superior for reducing regurgitation in regurgitative gastroesophageal reflux disease (GERD), and relief is sustained over 12 months.
Routine Esophagogastroduodenoscopy Has Little Impact on GERD Management
In most cases of diagnostic esophagogastroduodenoscopy (EGD) performed for refractory gastro-esophageal reflux disease (GERD), symptoms alone did not result in pathological findings that prompted a change in the patient’s GERD management.
Timed Barium Esophagram as Objective Marker for Long-Term Follow-Up of Esophageal Manometry
Roughly 2 years postsurgery, objective parameters for esophageal emptying via timed barium esophagram in patients who received per-oral endoscopic myotomy returned to presurgery levels, or worse.
Predictors and PPI Response in Children With Esophageal Dysfunction
Eosinophilic esophagitis (EoE) is a clinicopathologic disease for which proton pump inhibitors (PPIs) are now considered a treatment option. Of children with EoE, 32% responded to high-dose proton pump inhibitor (HDPPI) therapy.
Helicobacter Pylori Testing Should Include Patients With GERD From Endemic Areas
The study researchers concluded that recommendations for Helicobacter pylori screening should also include patients who exhibit GERD symptoms only, irrespective of regional origin.
Rapid Recurrence of Eosinophilic Esophagitis After Successful Treatment
EoE activity rapidly recurred after initial response to oral viscous budesonide (OVB) or fluticasone from a multidose inhaler (MDI), indicating the need for maintenance therapy for patients who achieve histologic response to topical steroids.
Oxycodone or Hydrocodone More Likely Than Tramadol to Cause OIED
Based on the results, it is recommended that opioid cessation be the first management strategy to consider when treating OIED.
Eosinophilic Esophagitis: A Chronic Allergic Disease
Eosinophilic esophagitis is marked by an inflammatory cascade that leads to subepithelial fibrosis and esophageal dysmotility.
CVS Halts Sales of OTC Zantac
CVS is the latest drugstore chain to stop selling over-the-counter Zantac (ranitidine), as well as the store’s own generic version of the heartburn medicine, because of contamination with a known carcinogen.
Ranitidine Recall Issued Following Discovery of NDMA
At this time, the Company has not received any adverse event reports related to use of the recalled product.
Maker Halts Distribution of Generic Zantac Due to Possible Carcinogen
Novartis, the maker of a generic form of Zantac, said Wednesday it will cease distribution of the medicine after investigations suggested that generic and branded versions contain a known carcinogen.
ASGE Recommendations for Screening and Surveillance of Barrett’s Esophagus
The goal of the ASGE guidelines is to impact the progression of Barrett’s esophagus and improve stage-dependent survival in esophageal adenocarcinoma.
Exploring Potassium-Competitive Acid Blockers: The Next Generation of PPIs
Because of the tolerability and enhanced effectiveness of P-CABs, it is very likely that they will change the future of treatment of acid-related disorders.
FDA: Zantac May Contain Small Amounts of Known Carcinogen
A substance that could cause cancer has been found in some ranitidine heartburn and ulcer medicines, including the brand-name drug Zantac, and the source of this contamination is being investigated.
FDA: Nitrosamine Impurity Identified in Commonly Used Acid Suppressant
NDMA was one of several nitrosamine impurities implicated in the massive recall of angiotensin II receptor blockers (ARBs) since last year.
Proton Pump Inhibitor Therapy Deemed Safe at 3 Years
Using an ELISA model, researchers have confirmed the high sensitivity and specificity of the monoclonal antibody Das-1 in detecting pancreatic cystic lesions (PCLs) with a risk for malignancy.
New Perspectives in the Management of Superficial Esophageal Cancer
For large, protruding or poorly lifting lesions, researchers indicate endoscopic submucosal dissection may prove to be more efficacious.
Assessment of Endoscopic Submucosal Dissection for Early Barrett’s Neoplasia
Although the results of ESD were generally positive in managing Barrett’s neoplasia, procedural improvements are needed ESD is to replace piecemeal endoscopic mucosal resection.
Benralizumab Receives Orphan Drug Status for Eosinophilic Esophagitis
The disease may manifest in patients with symptoms of chronic pain, difficulty swallowing, poor growth, malnutrition, and weight loss.
Certain Dietary Supplements Tied to Dysphagia, Choking in Seniors
Of the roughly two-thirds of reports of swallowing problems that included age data, more than three-quarters (76.8 percent) involved adults aged 65 years or older.
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