PPI Use Is Negative Prognostic Marker in Urothelial Cancer
For patients with advanced urothelial cancer treated with atezolizumab, proton pump inhibitor use is a negative prognostic marker.
Gastroesophageal Reflux Disease (GERD)
GERD
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No Difference in Clinical Outcomes by Cryotherapy Modality for Dysplastic Barrett Esophagus Treatment
Both cryoballoon and cryospray ablation therapies are effective in eradicating dysplastic Barrett esophagus.
Coffee, Tea, Soda Tied to Higher Risk for Gastroesophageal Reflux
Coffee, tea, and soda are associated with an increased risk for gastroesophageal reflux symptoms among middle-aged women.
Genomic Instability Predicts Risk of Progression for Barrett Esophagus
Genomic copy number instability predicted the risk of disease progression among patients with Barrett esophagus years beforehand.
Dupilumab Gets Breakthrough Therapy Status for Eosinophilic Esophagitis
The designation was based on results from Part A of a double-blind, placebo-controlled, pivotal phase 3 trial.
Findings Support Per-Oral Endoscopic Myotomy as Safe, Effective for Esophagogastric Junction Outflow Obstruction
Results of a multicenter, retrospective study of per-oral endoscopic myotomy (POEM) for EGJOO suggest that POEM is an effective and safe therapy.
Sleeve Gastrectomy Linked to High Prevalence of Barrett Esophagus
Patients undergoing sleeve gastrectomy sometimes develop gastroesophageal reflux disease, a major risk factor for Barrett’s esophagus; therefore, researchers investigated whether patients with SG have a high rate of BE.
Budesonide Orodispersible Tablets Effectively Bring EoE Into Remission
This phase 3 trial examined whether budesonide orodispersible tablets (0.5 mg or 1 mg, twice daily), with ≤48 weeks of treatment, was superior to placebo in maintaining remission of eosinophilic esophagitis.
Peroral Endoscopic Myotomy Safe, Effective in Patients on Antithrombotics
Investigators sought to determine whether peroral endoscopic myotomy is safe in patients receiving antithrombotic therapy and examined its clinical success and postprocedural rates of GERD.
Proton Pump Inhibitors and COVID-19: Is There an Increased Risk?
A team of investigators assessed the potential for use of proton pump inhibitors to affect the risk of COVID-19 infection.
PPI Use and Dementia Development: Is There a Link?
PPIs are frequently used off-label and are easily accessible as over-the-counter products, contributing to the potential for adverse events or drug-drug interactions.
Risk for COVID-19 Increased for Adults Taking PPIs
Adults taking proton pump inhibitors have an increased risk for having a positive COVID-19 test, with evidence of a dose-response relationship.
Proton Pump Inhibitors Used Inappropriately in Approximately 40% of Outpatient Procedures
Proton pump inhibitors are used inappropriately in approximately 40% of outpatients, indicating limited attention to guidelines.
Proton Pump Inhibitors May Up Death Risk in Kidney Transplant Recipients
In a study of kidney transplant recipients, PPI users had an almost 2-fold increased risk of mortality compared with nonusers.
Prevalence of Pediatric Eosinophilic Esophagitis in Medicaid Beneficiaries Lower in Impoverished, Rural Areas
The prevalence of pediatric eosinophilic esophagitis (EoE) may be lower among children living in impoverished areas compared with others.
Monoclonal Antibody Shows Long-Term Efficacy in Eosinophilic Esophagitis
An international, multicenter study was conducted to assess the long-term safety and efficacy of an experimental monoclonal antibody against interleukin-13 in patients with eosinophilic esophagitis.
Barrett Esophagus Recurrence After Complete Eradication of Intestinal Metaplasia
Surveillance recommendations are based on the initial grade of dysplasia.
FDA: All Ranitidine Products Must Be Removed From the Market
According to the results of tests conducted by the Agency, NDMA levels in ranitidine products can increase over time under normal storage conditions.
Proton Pump Inhibitors May Increase Fracture Risk in Children
A small but significant risk was seen for upper-limb and lower-limb fractures in children who received proton pump inhibitors.
Low Recurrence of Intestinal Metaplasia After Endoscopic Eradication Therapy
Patients with Barrett’s esophagus undergoing endoscopic eradication therapy demonstrated a low rate of recurrence of intestinal metaplasia and dysplasia after complete eradication of intestinal metaplasia.
Electronic Nose Device Can Detect Barrett Esophagus in Exhaled Breath
An electronic nose that measures volatile organic compounds can detect Barrett esophagus.
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