PPIs used Inappropriately in Approximately 40% of Outpatient Procedures
Proton pump inhibitors are used inappropriately in approximately 40% of outpatients, indicating limited attention to guidelines.
Gastroesophageal Reflux Disease (GERD)
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Proton Pump Inhibitors May Up Death Risk in Kidney Transplant Recipients
In a study of kidney transplant recipients, PPI users had an almost 2-fold increased risk of mortality compared with nonusers.
Prevalence of Pediatric Eosinophilic Esophagitis in Medicaid Beneficiaries Lower in Impoverished, Rural Areas
The prevalence of pediatric eosinophilic esophagitis (EoE) may be lower among children living in impoverished areas compared with others.
Monoclonal Antibody Shows Long-Term Efficacy in Eosinophilic Esophagitis
An international, multicenter study was conducted to assess the long-term safety and efficacy of an experimental monoclonal antibody against interleukin-13 in patients with eosinophilic esophagitis.
Barrett Esophagus Recurrence After Complete Eradication of Intestinal Metaplasia
Surveillance recommendations are based on the initial grade of dysplasia.
FDA: All Ranitidine Products Must Be Removed From the Market
According to the results of tests conducted by the Agency, NDMA levels in ranitidine products can increase over time under normal storage conditions.
Proton Pump Inhibitors May Increase Fracture Risk in Children
A small but significant risk was seen for upper-limb and lower-limb fractures in children who received proton pump inhibitors.
Low Recurrence of Intestinal Metaplasia After Endoscopic Eradication Therapy
Patients with Barrett’s esophagus undergoing endoscopic eradication therapy demonstrated a low rate of recurrence of intestinal metaplasia and dysplasia after complete eradication of intestinal metaplasia.
Electronic Nose Device Can Detect Barrett Esophagus in Exhaled Breath
An electronic nose that measures volatile organic compounds can detect Barrett esophagus.
Recommendations Issued for Surgical, Endoscopic GERD Interventions Based on PPI Response
A multidisciplinary team of surgeons and interventional gastroenterologists have released recommendations for managing patients GERD based on response to PPIs.
Barrett Esophagus: Is there an ADR equivalent?
As a precursor to esophageal adenocarcinoma, Barrett esophagus is a crucial diagnosis for gastroenterologists to make during upper endoscopy.
Machine Learning Could Aid Diagnosis of Barrett’s Esophagus, Avoid Invasive Testing
A risk prediction model consisting of 8 independent diagnostics can provide potential insight into a patient’s risk for Barrett’s esophagus before endoscopy, according to a study in published in Lancet Digital Health.
Two More Heartburn Meds Recalled Due to Possible Carcinogen
The U.S. Food and Drug Administration is adding to a list of recalled lots of popular heartburn medications — including generic forms of Zantac — because the pills might contain small amounts of the suspected carcinogen N-nitrosodimethylamine.
Recall: NDMA Identified in Mylan’s Nizatidine Capsules
Mylan has announced a recall of 3 lots of Nizatidine Capsules as the products were manufactured with an active pharmaceutical ingredient (API) that contained trace amounts of N-nitrosodimethylamine (NDMA), a probable human carcinogen.
GERD and the Elderly Patient: Clinical Considerations
Elderly patients have a higher tolerance for GERD symptoms compared with younger patients; therefore, these symptoms may be under-reported.
Eosinophilic Esophagitis Does Not Negatively Affect Pregnancy Outcomes
Patients with female eosinophilic esophagitis considering pregnancy should be informed that to date, no increased maternal and fetal risk was observed in pregnant patients with EoE on and off EoE-specific medication.
Acetic Acid Biopsies Feasible and Acceptable in Barrett’s Surveillance
The acetic acid method of biopsy (Portsmouth protocol) was shown to be feasible in Barrett’s surveillance, with clinician and patient acceptance; moreover, the reduced number of biopsies with this technique indicate that acetic acid biopsies could produce cost savings.
Reflux in Pediatric Esophageal Atresia: pH and Impedance Monitoring
Most infants and school-aged children with EA off medication have a normal [reflux index], yet experience a significant number of nonacid RBM. After manual revision of the tracings, a high percentage of RBM was deleted.
The International Blue-Light Imaging for Barrett’s Neoplasia Classification
BLI is a promising tool for optical diagnosis in Barrett’s, although further studies need to be undertaken real-time in a general Barrett’s surveillance population.
Updated Eosinophilic Esophagitis Guidelines Encourage Interdisciplinary Collaboration
New guidelines on eosinophilic esophagitis management were recently developed with the aim of informing treatment decisions among pediatric and adult allergists and gastroenterologists.
FDA: NDMA Identified in Common Diabetes Drug Outside US
The FDA is investigating metformin products in the US based on these reports; currently no metformin products have been recalled.
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