GERD May Increase Risk for Subsequent NSCLC
Investigators studied the association between gastroesophageal reflux disease and non–small lung cancer in a retrospective case-control study.
Gastroesophageal Reflux Disease (GERD)
GERD
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Endoscopic Submucosal Dissection May Be Superior to Cap-Assisted Endoscopic Mucosal Resection in Barrett Esophagus
Investigators compared the histological outcomes of endoscopic submucosal dissection with those of cap-assisted endoscopic mucosal resection.
Novel Budesonide Oral Suspension Gets Priority Review for Eosinophilic Esophagitis
The FDA has accepted for review the NDA and granted Priority Review to TAK-721 (budesonide oral suspension) for the treatment of eosinophilic esophagitis.
Pandemic-Related Delays in Cancer Screenings and Treatment Threaten Progress in Cancer Mortality Rates
If the current COVID-19 trends persist, the NCI estimates that the pandemic’s impact could threaten the trend of annually decreasing cancer mortality seen in the US since 1990.
Targeted Therapies, Immunotherapies, and Immunomodulators: A Quick Guide to Cancer Therapy
Sometimes the distinctions between cancer treatment groups are a little blurry. Here’s a guide to their definitions and origins.
Recurrent GEJIM After Endoscopic Therapy for Barrett Esophagus Not Associated With Higher Risk for Dysplasia
Investigators assessed whether recurrent gastroesophageal junction intestinal metaplasia is associated with increased risk for subsequent dysplasia and whether endoscopic treatment lowers this risk if so.
Proton Pump Inhibitor Use May Decrease Urinary Citrate Excretion
A reduction in urinary citrate levels may be the mechanism underlying the higher incidence of kidney stones in patients taking PPIs, according to investigators.
Increased GERD Risk in End-Stage Lung Disease Without Esophageal Disease
End-stage lung disease may significantly increase the risk for gastroesophageal reflux disease (GERD) in patients undergoing lung transplant without primary esophageal disease.
Clinical Program for Investigational GERD Drug Discontinued
The bile acid sequestrant was designed to be maintained in the stomach over an extended period of time where it was expected to intercept bile before it reached the esophagus.
Proton Pump Inhibitor Use Linked to Increased T2D Risk
Regular use of proton pump inhibitors is associated with an increased risk for type 2 diabetes.
Acid Reflux Monitoring May Indicate Candidates for PPI Discontinuation in Those With Typical Reflux Symptoms
Acid exposure measured via reflux monitoring can be predicative of a patient’s ability to discontinue PPI use without symptom escalation.
No Difference in Clinical Outcomes by Cryotherapy Modality for Dysplastic Barrett Esophagus Treatment
Both cryoballoon and cryospray ablation therapies are effective in eradicating dysplastic Barrett esophagus.
PPI Use Is Negative Prognostic Marker in Urothelial Cancer
For patients with advanced urothelial cancer treated with atezolizumab, proton pump inhibitor use is a negative prognostic marker.
Coffee, Tea, Soda Tied to Higher Risk for Gastroesophageal Reflux
Coffee, tea, and soda are associated with an increased risk for gastroesophageal reflux symptoms among middle-aged women.
Genomic Instability Predicts Risk of Progression for Barrett Esophagus
Genomic copy number instability predicted the risk of disease progression among patients with Barrett esophagus years beforehand.
Dupilumab Gets Breakthrough Therapy Status for Eosinophilic Esophagitis
The designation was based on results from Part A of a double-blind, placebo-controlled, pivotal phase 3 trial.
Findings Support Per-Oral Endoscopic Myotomy as Safe, Effective for Esophagogastric Junction Outflow Obstruction
Results of a multicenter, retrospective study of per-oral endoscopic myotomy (POEM) for EGJOO suggest that POEM is an effective and safe therapy.
Sleeve Gastrectomy Linked to High Prevalence of Barrett Esophagus
Patients undergoing sleeve gastrectomy sometimes develop gastroesophageal reflux disease, a major risk factor for Barrett’s esophagus; therefore, researchers investigated whether patients with SG have a high rate of BE.
Budesonide Orodispersible Tablets Effectively Bring EoE Into Remission
This phase 3 trial examined whether budesonide orodispersible tablets (0.5 mg or 1 mg, twice daily), with ≤48 weeks of treatment, was superior to placebo in maintaining remission of eosinophilic esophagitis.
Peroral Endoscopic Myotomy Safe, Effective in Patients on Antithrombotics
Investigators sought to determine whether peroral endoscopic myotomy is safe in patients receiving antithrombotic therapy and examined its clinical success and postprocedural rates of GERD.
Proton Pump Inhibitors and COVID-19: Is There an Increased Risk?
A team of investigators assessed the potential for use of proton pump inhibitors to affect the risk of COVID-19 infection.
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