GERD and the Elderly Patient: Clinical Considerations
Elderly patients have a higher tolerance for GERD symptoms compared with younger patients; therefore, these symptoms may be under-reported.
Gastroesophageal Reflux Disease (GERD)
GERD
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Two More Heartburn Meds Recalled Due to Possible Carcinogen
The U.S. Food and Drug Administration is adding to a list of recalled lots of popular heartburn medications — including generic forms of Zantac — because the pills might contain small amounts of the suspected carcinogen N-nitrosodimethylamine.
Recall: NDMA Identified in Mylan’s Nizatidine Capsules
Mylan has announced a recall of 3 lots of Nizatidine Capsules as the products were manufactured with an active pharmaceutical ingredient (API) that contained trace amounts of N-nitrosodimethylamine (NDMA), a probable human carcinogen.
Eosinophilic Esophagitis Does Not Negatively Affect Pregnancy Outcomes
Patients with female eosinophilic esophagitis considering pregnancy should be informed that to date, no increased maternal and fetal risk was observed in pregnant patients with EoE on and off EoE-specific medication.
Acetic Acid Biopsies Feasible and Acceptable in Barrett’s Surveillance
The acetic acid method of biopsy (Portsmouth protocol) was shown to be feasible in Barrett’s surveillance, with clinician and patient acceptance; moreover, the reduced number of biopsies with this technique indicate that acetic acid biopsies could produce cost savings.
Reflux in Pediatric Esophageal Atresia: pH and Impedance Monitoring
Most infants and school-aged children with EA off medication have a normal [reflux index], yet experience a significant number of nonacid RBM. After manual revision of the tracings, a high percentage of RBM was deleted.
The International Blue-Light Imaging for Barrett’s Neoplasia Classification
BLI is a promising tool for optical diagnosis in Barrett’s, although further studies need to be undertaken real-time in a general Barrett’s surveillance population.
Updated Eosinophilic Esophagitis Guidelines Encourage Interdisciplinary Collaboration
New guidelines on eosinophilic esophagitis management were recently developed with the aim of informing treatment decisions among pediatric and adult allergists and gastroenterologists.
FDA: NDMA Identified in Common Diabetes Drug Outside US
The FDA is investigating metformin products in the US based on these reports; currently no metformin products have been recalled.
Esophageal Motility Abnormalities Associated With Severe Skin Thickness
There are significant correlations between esophageal motility abnormalities and severe skin thickness.
Long-term Proton Pump Inhibitor Therapy Not Associated With Adverse Events
Researchers assessed the association between long-term usage of PPIs and the adverse events of dementia, pneumonia, intestinal infections, and chronic kidney disease.
PPI Response and Role of Reflux in Eosinophilic Esophagitis Pathogenesis
The findings indicate that reflux plays a role in the pathogenesis of EoE, more relevant in PPI-responsive cases, and that PPIs mainly act by antireflux mechanisms, supporting long-term prescription in PPI-responsive EoE.
FDA: Testing Reveals Unacceptable Levels of NDMA in Two H2 Blockers
The FDA has released a summary of the results from tests evaluating ranitidine products for the probable carcinogen N-Nitrosodimethylamine.
Magnetic Sphincter Augmentation Superior to Proton Pump Inhibitor for Reducing Regurgitation in GERD
Compared with proton pump inhibitor (PPI) therapy, magnetic sphincter augmentation (MSA) was far superior for reducing regurgitation in regurgitative gastroesophageal reflux disease (GERD), and relief is sustained over 12 months.
Routine Esophagogastroduodenoscopy Has Little Impact on GERD Management
In most cases of diagnostic esophagogastroduodenoscopy (EGD) performed for refractory gastro-esophageal reflux disease (GERD), symptoms alone did not result in pathological findings that prompted a change in the patient’s GERD management.
Timed Barium Esophagram as Objective Marker for Long-Term Follow-Up of Esophageal Manometry
Roughly 2 years postsurgery, objective parameters for esophageal emptying via timed barium esophagram in patients who received per-oral endoscopic myotomy returned to presurgery levels, or worse.
Predictors and PPI Response in Children With Esophageal Dysfunction
Eosinophilic esophagitis (EoE) is a clinicopathologic disease for which proton pump inhibitors (PPIs) are now considered a treatment option. Of children with EoE, 32% responded to high-dose proton pump inhibitor (HDPPI) therapy.
Helicobacter Pylori Testing Should Include Patients With GERD From Endemic Areas
The study researchers concluded that recommendations for Helicobacter pylori screening should also include patients who exhibit GERD symptoms only, irrespective of regional origin.
Rapid Recurrence of Eosinophilic Esophagitis After Successful Treatment
EoE activity rapidly recurred after initial response to oral viscous budesonide (OVB) or fluticasone from a multidose inhaler (MDI), indicating the need for maintenance therapy for patients who achieve histologic response to topical steroids.
Oxycodone or Hydrocodone More Likely Than Tramadol to Cause OIED
Based on the results, it is recommended that opioid cessation be the first management strategy to consider when treating OIED.
Eosinophilic Esophagitis: A Chronic Allergic Disease
Eosinophilic esophagitis is marked by an inflammatory cascade that leads to subepithelial fibrosis and esophageal dysmotility.
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