Gastroesophageal Reflux Disease (GERD)

Latest News

Unexplained Gastrointestinal Disorders Remain Relatively Stable in a Specific Population Over 20 Years

By

Jessica Nye, PhD

Researchers analyzed the trends and prevalence of chronic, unexplained GI symptoms in a single community over a 20 year span.

Obstructive Sleep Apnea Syndrome May Reduce Hypopharyngeal Reflux Events in Laryngopharyngeal Reflux

By

Vincent Soreca

A team of investigators conducted a prospective study to explore the profile of patients with OSAS and LPR at the HEMII-pH and to compare the reflux findings with LPR patients without OSAS.

pH Meter and pH Paper May Be Useful for Monitoring Tube-Fed Children With Neurologic Impairment and GERD

By

Colby Stong

Investigators analyzed the agreement among pH paper, hand-held pH meters, and laboratory pH meters for gastric pH measurements in tube-fed children with neurological impairments and GERD.

Surgical Intervention for Acid-Reflux Control More Efficacious and Cost-Effective Than Long-Term PPI Use

By

Jessica Nye, PhD

Researchers assessed the efficacy and cost-effectiveness of proton pump inhibitors vs surgical intervention for acid reflux control.

Allergen Specific IgEs Used to Classify Patients With Esophageal Eosinophilia

By

Virginia A. Schad, PharmD, RPh

Investigators analyzed IgE-mediated allergic sensitization patterns in patients with esophageal eosinophilia.

PPI-Resistant Severe Reflux Esophagitis Reduces Saliva Secretion

By

Jessica Nye, PhD

Investigators examined saliva secretion and salivary epidermal growth factor in patients with proton pump inhibitor-resistant severe reflux esophagitis.

Path Modeling Helps Predict Disease Course in Patients With GERD

By

Virginia A. Schad, PharmD, RPh

Researchers aimed to identify disease markers in GERD to describe its progression and severity in patients with persisting symptoms.

Increased Risk of Eosinophilic Esophagitis in Children With IBD

By

Brandon May

Researchers evaluated the potential predictive characteristics of eosinophilic esophagitis following IBD diagnosis in children.

Active Eosinophilic Esophagitis Associated With Increased Asthma Severity

By

Virginia A. Schad, PharmD, RPh

Active eosinophilic esophagitis appears to be associated with lower lung function and increased asthma severity in children with comorbid asthma.

Notable Decline in Prevalence of Barrett Esophagus in Patients With GERD

By

Vincent Soreca

The prevalence of Barrett esophagus has noticeably declined in patients with gastroesophageal reflux disease (GERD) over the last 2 decades. Concurrent with this finding has been an increased trend in the use of proton pump inhibitors (PPIs) and aspirin therapy, as well as a decrease in cigarette smoking. It is therefore possible that these modifiable…

One Anastomosis Gastric Bypass in Patients With GERD, Hiatal Hernia

By

Virginia A. Schad, PharmD, RPh

A team of investigators assessed outcomes following one anastomosis gastric bypass in patients with gastroesophageal reflux disease and/or hiatal hernia.

Transoral Incisionless Fundoplication May Be Effective Alternative to Surgery for GERD

By

Colby Stong

The researchers conducted a literature search for studies that reported long-term outcomes of transoral incisionless fundoplication for treating refractory GERD and then pooled the data.

Antireflux Surgery in Younger Patients With GERD Without Severe Comorbidity

By

Virginia A. Schad, PharmD, RPh

The aim of this study was to identify absolute risks and risk factors of short-term outcomes in younger patients with primary laparoscopic and secondary antireflux surgery.

Cytosponge a Noninvasive Surveillance Approach for Residual Barrett Esophagus

By

Jessica Nye, PhD

A team of investigators sought to determine the ability of the Cytosponge to detect the persistence of Barrett esophagus following eradication therapy.

Budesonide Oral Suspension Improves Multiple Outcomes in Pediatric Eosinophilic Esophagitis

By

Brandon May

Budesonide oral suspension improved histologic, endoscopic, and both histologic and symptomatic outcomes in children with eosinophilic esophagitis compared with placebo.

Insulated-Tip Knife Tunneling Esophageal Endoscopic Submucosal Dissection: Japanese Technique Succeeds in the US

By

Vincent Soreca

A team of investigators conducted a prospective, single-center, observational study at the Cleveland Clinic to determine the safety and feasibility of IT-knife tunneling and C-shaped incision endoscopic submucosal dissection of the esophagus.

Influence of PPI Therapy on Outcome of Infliximab Therapy in IBD

By

Virginia A. Schad, PharmD, RPh

A team of investigators sought to determine how concomitant proton pump inhibitor treatment influences response to infliximab therapy in patients with inflammatory bowel disease.

GERD Linked to Squamous Cell Cancers of Larynx, Esophagus

Gastroesophageal reflux disease appears to be associated with an increased risk for squamous cell cancers of the larynx and esophagus.

Child Proton Pump Inhibitor Use May Increase Asthma Risk

Initiation of proton pump inhibitor (PPI) use is associated with an increased risk for asthma among children.

Fewer Diagnoses of Barrett Esophagus, Esophagogastric Cancer During COVID-19 Pandemic

By

Vincent Soreca

Researchers aimed to describe the impact of the COVID-19 pandemic on the diagnosis of Barrett esophagus and esophagogastric cancer in Northern Ireland.