Individuals with genetic variants linked to increased coffee consumption have reduced risk for gallstones.
Nearly half of patients with early-stage PBC progress to a more severe stage within 5 years. Progression is associated with increased risk of a clinical event, so surveillance is important for patients with early-stage PBC.
Researchers conducted a retrospective cohort study to determine the clinical features of pediatric patients with PSC in a Japanese cohort to evaluate long-term outcomes. They discovered that primary sclerosing cholangitis (PSC)-autoimmune hepatitis overlap is the primary phenotype linked to poor long-term outcomes.
The researchers observed an increased risk for acute gallbladder or biliary disease with liraglutide versus placebo (hazard ratio, 1.60). Similar findings were seen for each of the four categories of gallbladder- or biliary tract-related events (uncomplicated gallbladder stones, complicated gallbladder stones, cholecystitis with/without gallbladder stones, and biliary obstruction).
No significant differences in surgical complication risk were seen in early or delayed cholecystectomy for acute cholangitis and acute cholecystitis.
At a routine follow-up visit at the clinic a month prior, the patient reported consuming at least 2 bags of unpeeled lemons per day.