The U.S. Food and Drug Administration is adding to a list of recalled lots of popular heartburn medications — including generic forms of Zantac — because the pills might contain small amounts of the suspected carcinogen N-nitrosodimethylamine.
Mylan has announced a recall of 3 lots of Nizatidine Capsules as the products were manufactured with an active pharmaceutical ingredient (API) that contained trace amounts of N-nitrosodimethylamine (NDMA), a probable human carcinogen.
A convolutional neural networks-based approach to the analysis of images of histopathologic slides does not require prior slide annotation by a pathologist.
Patients with female eosinophilic esophagitis considering pregnancy should be informed that to date, no increased maternal and fetal risk was observed in pregnant patients with EoE on and off EoE-specific medication.
The acetic acid method of biopsy (Portsmouth protocol) was shown to be feasible in Barrett’s surveillance, with clinician and patient acceptance; moreover, the reduced number of biopsies with this technique indicate that acetic acid biopsies could produce cost savings.
Most infants and school-aged children with EA off medication have a normal [reflux index], yet experience a significant number of nonacid RBM. After manual revision of the tracings, a high percentage of RBM was deleted.
BLI is a promising tool for optical diagnosis in Barrett’s, although further studies need to be undertaken real-time in a general Barrett’s surveillance population.
Esophageal stents may have a role as a bridge to definitive surgery but complete stricture resolution poststenting is extremely unlikely with a high re-intervention rate.
New guidelines on eosinophilic esophagitis management were recently developed with the aim of informing treatment decisions among pediatric and adult allergists and gastroenterologists.
Patients with hepatitis C virus (HCV) and cirrhosis can develop high-risk gastroesophageal varices (GEV) after sustained virological response (SVR). Surveillance is especially recommended in those with GEV before antiviral treatment.
Hepatitis C virus (HCV) sustained virologic response following direct-acting antiviral (DAA) therapy is associated with lower risk for variceal bleeding.
The findings indicate that reflux plays a role in the pathogenesis of EoE, more relevant in PPI-responsive cases, and that PPIs mainly act by antireflux mechanisms, supporting long-term prescription in PPI-responsive EoE.
Compared with proton pump inhibitor (PPI) therapy, magnetic sphincter augmentation (MSA) was far superior for reducing regurgitation in regurgitative gastroesophageal reflux disease (GERD), and relief is sustained over 12 months.
In most cases of diagnostic esophagogastroduodenoscopy (EGD) performed for refractory gastro-esophageal reflux disease (GERD), symptoms alone did not result in pathological findings that prompted a change in the patient’s GERD management.
Roughly 2 years postsurgery, objective parameters for esophageal emptying via timed barium esophagram in patients who received per-oral endoscopic myotomy returned to presurgery levels, or worse.
Eosinophilic esophagitis (EoE) is a clinicopathologic disease for which proton pump inhibitors (PPIs) are now considered a treatment option. Of children with EoE, 32% responded to high-dose proton pump inhibitor (HDPPI) therapy.
EoE activity rapidly recurred after initial response to oral viscous budesonide (OVB) or fluticasone from a multidose inhaler (MDI), indicating the need for maintenance therapy for patients who achieve histologic response to topical steroids.
