Barrett Esophagus: Is there an ADR equivalent?
As a precursor to esophageal adenocarcinoma, Barrett esophagus is a crucial diagnosis for gastroenterologists to make during upper endoscopy.
Esophagus
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Machine Learning Could Aid Diagnosis of Barrett's Esophagus, Avoid Invasive Testing
A risk prediction model consisting of 8 independent diagnostics can provide potential insight into a patient’s risk for Barrett’s esophagus before endoscopy, according to a study in published in Lancet Digital Health.
Screening for Adrenal Insufficiency in Children With Eosinophilic Esophagitis
Gastroenterologists who are members of an EoE consortia are much more likely to routinely screen for adrenal insufficiency in children with eosinophilic esophagitis who are being treated with topical corticosteroids.
No Local Control, OS Benefit for RT Dose Escalation in Esophageal Cancer
In this study, patients were randomly assigned to receive standard-dose RT or standard-dose RT plus an integrated RT boost to the primary tumor.
Avelumab Maintenance: No OS Benefit vs Chemotherapy in HER2- GI Cancers
Fewer treatment-related grade 3 or higher adverse events were reported in the avelumab arm compared with the chemotherapy arm.
Two More Heartburn Meds Recalled Due to Possible Carcinogen
The U.S. Food and Drug Administration is adding to a list of recalled lots of popular heartburn medications — including generic forms of Zantac — because the pills might contain small amounts of the suspected carcinogen N-nitrosodimethylamine.
Recall: NDMA Identified in Mylan’s Nizatidine Capsules
Mylan has announced a recall of 3 lots of Nizatidine Capsules as the products were manufactured with an active pharmaceutical ingredient (API) that contained trace amounts of N-nitrosodimethylamine (NDMA), a probable human carcinogen.
A Convolutional Neural Networks-Based Approach to the Analysis of Esophageal Biopsy Specimens
A convolutional neural networks-based approach to the analysis of images of histopathologic slides does not require prior slide annotation by a pathologist.
GERD and the Elderly Patient: Clinical Considerations
Elderly patients have a higher tolerance for GERD symptoms compared with younger patients; therefore, these symptoms may be under-reported.
Eosinophilic Esophagitis Does Not Negatively Affect Pregnancy Outcomes
Patients with female eosinophilic esophagitis considering pregnancy should be informed that to date, no increased maternal and fetal risk was observed in pregnant patients with EoE on and off EoE-specific medication.
Acetic Acid Biopsies Feasible and Acceptable in Barrett’s Surveillance
The acetic acid method of biopsy (Portsmouth protocol) was shown to be feasible in Barrett’s surveillance, with clinician and patient acceptance; moreover, the reduced number of biopsies with this technique indicate that acetic acid biopsies could produce cost savings.
Reflux in Pediatric Esophageal Atresia: pH and Impedance Monitoring
Most infants and school-aged children with EA off medication have a normal [reflux index], yet experience a significant number of nonacid RBM. After manual revision of the tracings, a high percentage of RBM was deleted.
The International Blue-Light Imaging for Barrett's Neoplasia Classification
BLI is a promising tool for optical diagnosis in Barrett’s, although further studies need to be undertaken real-time in a general Barrett’s surveillance population.
Stenting May Not Fully Resolve Refractory Esophageal Strictures in Children
Esophageal stents may have a role as a bridge to definitive surgery but complete stricture resolution poststenting is extremely unlikely with a high re-intervention rate.
New EoE Guidelines Encourage Collaboration Among Clinicians
New guidelines on eosinophilic esophagitis management were recently developed with the aim of informing treatment decisions among pediatric and adult allergists and gastroenterologists.
FDA: NDMA Identified in Common Diabetes Drug Outside US
The FDA is investigating metformin products in the US based on these reports; currently no metformin products have been recalled.
Development of High-Risk GEV After SVR Possible in HCV Infected Cirrhosis
Patients with hepatitis C virus (HCV) and cirrhosis can develop high-risk gastroesophageal varices (GEV) after sustained virological response (SVR). Surveillance is especially recommended in those with GEV before antiviral treatment.
Esophageal Motility Abnormalities Associated With Severe Skin Thickness
There are significant correlations between esophageal motility abnormalities and severe skin thickness.
DAAs May Reduce Risk for Variceal Bleeding in HCV
Hepatitis C virus (HCV) sustained virologic response following direct-acting antiviral (DAA) therapy is associated with lower risk for variceal bleeding.
PPI Response and Role of Reflux in Eosinophilic Esophagitis Pathogenesis
The findings indicate that reflux plays a role in the pathogenesis of EoE, more relevant in PPI-responsive cases, and that PPIs mainly act by antireflux mechanisms, supporting long-term prescription in PPI-responsive EoE.
MSA Superior to Proton Pump Inhibitor for Reducing Regurgitation in GERD
Compared with proton pump inhibitor (PPI) therapy, magnetic sphincter augmentation (MSA) was far superior for reducing regurgitation in regurgitative gastroesophageal reflux disease (GERD), and relief is sustained over 12 months.
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