Esophagus

Latest Articles

Tezepelumab Granted Orphan Drug Status for Eosinophilic Esophagitis

By

Brian Park, PharmD

Tezepelumab is a first-in-class human monoclonal antibody that works by blocking thymic stromal lymphopoietin.

Nivolumab Plus Chemotherapy in GC/GEJC/EAC

By

Andrea S. Blevins Primeau, PhD, MBA

The addition of nivolumab to chemotherapy demonstrated continuing improved survival compared with chemotherapy alone after 24 months of follow-up.

Tislelizumab Under Review for Esophageal Squamous Cell Carcinoma

By

Brian Park, PharmD

The application is supported by data from the phase 3 RATIONALE 302 trial.

Assessment of Risk Prediction Model for 90-Day Mortality After Esophagectomy for Cancer

By

Vincent Soreca

Investigators sought to develop and validate a risk prediction model for death within 90 days after esophagectomy for cancer, utilizing the IESG database

Hypervigilance and Symptom-Specific Anxiety in Patients With EoE

By

Bradley van Paridon

Investigators assessed the presence and predictive relationship of hypervigilance and symptom-specific anxiety in patients with eosinophilic esophagitis.

Prevalence of Cardiac-Specific Mortality in Major GI Cancers

By

Rita Aghjayan

Investigators assessed the cardiac-specific mortality rate among patients with major GI cancers, as well as the relationship between radiation and chemotherapy with survival outcomes.

Barrett Esophagus: AI System Reliably Quantifies in Real-Time

By

Rita Aghjayan

Investigators evaluated the accuracy of AI assessment of Prague classification and Barrett area quantification from 3D reconstructions of the esophageal surface from 2D endoscopic imaging.

Neoadjuvant Chemoradiotherapy Added to Surgery for Locally Advanced ESCC

By

Jennifer Champagne, PharmD, RPh, BCPS

Investigators compared the efficacy of neoadjuvant chemoradiotherapy plus surgery vs surgery alone for treatment of advanced esophageal squamous cell carcinoma.

A Case of Sudden-Onset Dysphagia During Lunch, Unresolved by PPIs

By

Karmen Elsen, MPA, PA-C

A patient presenting with sudden-onset dysphagia and vomiting initially is diagnosed with GERD but does not respond to PPIs. What is your diagnosis?

Intrathoracic vs Cervical Anastomosis Following Transthoracic MIE for Esophageal Cancer

By

Vincent Soreca

Investigators compared outcomes of intrathoracic vs cervical anastomosis following transthoracic minimally invasive esophagectomy.

Reduced-Intensity Chemotherapy in Older, Frail Patients With Gastroesophageal Cancer

By

Rita Aghjayan

Investigators aimed to determine optimal chemotherapy dosing for older, frail patients with gastroesophageal cancer and use of geriatric assessment as a decision making tool.

Optimal Age to Stop Surveillance of Patients With NDBE Dependent on Sex and General Health

By

Colby Stong

Investigators aimed to determine the ideal age to discontinue surveillance in patients with non-dysplastic Barrett esophagus based on sex and comorbidities.

Hill Grade on EGD Is Associated With GER in Children and Adolescents

By

Colby Stong

Investigators sought to evaluate the relationship between Hill grade confirmed with EGD and the degree of gastroesophageal reflux in children with GERD.

Achalasia May Be Associated With Salivary VZV DNA

By

Colby Stong

Researchers investigated whether varicella zoster virus is linked to achalasia.

Nonendoscopic Detection for Barrett Esophagus May Also Identify Esophageal Adenocarcinoma

By

Rita Aghjayan

Researchers reviewed the current status of and advances in the detection of Barrett esophagus and risks for esophageal adenocarcinoma.

Etrasimod Granted Orphan Drug Status for Eosinophilic Esophagitis

By

Brian Park, PharmD

Etrasimod is an investigational, next generation, once-daily, oral, highly selective sphingosine 1-phosphate receptor modulator.

Opdivo Approved as Adjuvant Treatment for Completely Resected Esophageal, GEJ Cancer

By

Brian Park, PharmD

The approval was based on data from the phase 3 CheckMate-577 trial which included 794 adults with completely resected esophageal or GEJ cancer who had residual pathologic disease following neoadjuvant CRT.

Dysphagia Prevalence, Characteristics Among Patients With OSA

By

Sheila Jacobs

Approximately one-sixth of patients with obstructive sleep apnea (OSA) have demonstrated symptoms of dysphagia.

Keytruda Combo Approved for First-Line Treatment of HER2-Positive Gastric Cancer

By

Diana Ernst, RPh

The accelerated approval was based on data from the KEYNOTE-811 study.

RFA with ER Effective, Durable Treatment for BE

By

Emily Pond

Investigators examined short-term and long-term outcomes of patients treated for BE with dysplasia and/or early cancer, according to a uniform protocol.