HPV Biomarkers Linked to High-Grade Esophageal Dysplasia
Low expression of the HPV-related marker cyclin D1 appears to be an independent prognostic marker in Barrett high-grade dysplasia and esophageal adenocarcinoma.
Esophagus
ESOPHAGUS
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Low Recurrence of Intestinal Metaplasia After Endoscopic Eradication Therapy
Patients with Barrett’s esophagus undergoing endoscopic eradication therapy demonstrated a low rate of recurrence of intestinal metaplasia and dysplasia after complete eradication of intestinal metaplasia.
Abnormal OGTT May Indicate Dumping Syndrome in Infants With Esophageal Atresia
An abnormal glucose tolerance test to screen for potential dumping syndrome around 3 months of age should be considered in infants born with esophageal atresia.
Electronic Nose Device Can Detect Barrett Esophagus in Exhaled Breath
An electronic nose that measures volatile organic compounds can detect Barrett esophagus.
A Closer Look at Metformin and Esophageal Squamous Cell Carcinoma
Esophageal squamous cell carcinoma represents the predominant histologic type of esophageal cancer worldwide.
Barrett Esophagus: Is there an ADR equivalent?
As a precursor to esophageal adenocarcinoma, Barrett esophagus is a crucial diagnosis for gastroenterologists to make during upper endoscopy.
Machine Learning Could Aid Diagnosis of Barrett's Esophagus, Avoid Invasive Testing
A risk prediction model consisting of 8 independent diagnostics can provide potential insight into a patient’s risk for Barrett’s esophagus before endoscopy, according to a study in published in Lancet Digital Health.
Screening for Adrenal Insufficiency in Children With Eosinophilic Esophagitis
Gastroenterologists who are members of an EoE consortia are much more likely to routinely screen for adrenal insufficiency in children with eosinophilic esophagitis who are being treated with topical corticosteroids.
No Local Control, OS Benefit for RT Dose Escalation in Esophageal Cancer
In this study, patients were randomly assigned to receive standard-dose RT or standard-dose RT plus an integrated RT boost to the primary tumor.
Avelumab Maintenance: No OS Benefit vs Chemotherapy in HER2- GI Cancers
Fewer treatment-related grade 3 or higher adverse events were reported in the avelumab arm compared with the chemotherapy arm.
Two More Heartburn Meds Recalled Due to Possible Carcinogen
The U.S. Food and Drug Administration is adding to a list of recalled lots of popular heartburn medications — including generic forms of Zantac — because the pills might contain small amounts of the suspected carcinogen N-nitrosodimethylamine.
Recall: NDMA Identified in Mylan’s Nizatidine Capsules
Mylan has announced a recall of 3 lots of Nizatidine Capsules as the products were manufactured with an active pharmaceutical ingredient (API) that contained trace amounts of N-nitrosodimethylamine (NDMA), a probable human carcinogen.
A Convolutional Neural Networks-Based Approach to the Analysis of Esophageal Biopsy Specimens
A convolutional neural networks-based approach to the analysis of images of histopathologic slides does not require prior slide annotation by a pathologist.
GERD and the Elderly Patient: Clinical Considerations
Elderly patients have a higher tolerance for GERD symptoms compared with younger patients; therefore, these symptoms may be under-reported.
Eosinophilic Esophagitis Does Not Negatively Affect Pregnancy Outcomes
Patients with female eosinophilic esophagitis considering pregnancy should be informed that to date, no increased maternal and fetal risk was observed in pregnant patients with EoE on and off EoE-specific medication.
Acetic Acid Biopsies Feasible and Acceptable in Barrett’s Surveillance
The acetic acid method of biopsy (Portsmouth protocol) was shown to be feasible in Barrett’s surveillance, with clinician and patient acceptance; moreover, the reduced number of biopsies with this technique indicate that acetic acid biopsies could produce cost savings.
Reflux in Pediatric Esophageal Atresia: pH and Impedance Monitoring
Most infants and school-aged children with EA off medication have a normal [reflux index], yet experience a significant number of nonacid RBM. After manual revision of the tracings, a high percentage of RBM was deleted.
The International Blue-Light Imaging for Barrett's Neoplasia Classification
BLI is a promising tool for optical diagnosis in Barrett’s, although further studies need to be undertaken real-time in a general Barrett’s surveillance population.
Stenting May Not Fully Resolve Refractory Esophageal Strictures in Children
Esophageal stents may have a role as a bridge to definitive surgery but complete stricture resolution poststenting is extremely unlikely with a high re-intervention rate.
New EoE Guidelines Encourage Collaboration Among Clinicians
New guidelines on eosinophilic esophagitis management were recently developed with the aim of informing treatment decisions among pediatric and adult allergists and gastroenterologists.
FDA: NDMA Identified in Common Diabetes Drug Outside US
The FDA is investigating metformin products in the US based on these reports; currently no metformin products have been recalled.
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