Clinical Outcomes Similar Regardless of Cryotherapy Modality
Both cryoballoon and cryospray ablation therapies are effective in eradicating dysplastic Barrett esophagus.
Esophagus
ESOPHAGUS
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Pembrolizumab Plus Chemotherapy Prolonged Survival in Esophageal or EGJ Cancers
First-line pembrolizumab plus chemotherapy prolonged survival among patients with advanced esophageal or esophagogastric junction cancer.
First-Line Nivolumab Plus Chemotherapy Improves Survival in GC, GEJC, and EAC
Nivolumab plus chemotherapy prolonged survival of patients with advanced gastric, gastroesophageal junction, and esophageal cancers compared with chemotherapy.
Genomic Instability Predicts Risk of Progression for Barrett Esophagus
Genomic copy number instability predicted the risk of disease progression among patients with Barrett esophagus years beforehand.
Dupilumab Gets Breakthrough Therapy Status for Eosinophilic Esophagitis
The designation was based on results from Part A of a double-blind, placebo-controlled, pivotal phase 3 trial.
Role of POEM for EGJOO Evaluated
Results of a multicenter, retrospective study of per-oral endoscopic myotomy (POEM) for EGJOO suggest that POEM is an effective and safe therapy.
Barrett Esophagus Quite Prevalent After SG
Patients undergoing sleeve gastrectomy sometimes develop gastroesophageal reflux disease, a major risk factor for Barrett’s esophagus; therefore, researchers investigated whether patients with SG have a high rate of BE.
BOTs Effectively Bring EoE Into Remission
This phase 3 trial examined whether budesonide orodispersible tablets (0.5 mg or 1 mg, twice daily), with ≤48 weeks of treatment, was superior to placebo in maintaining remission of eosinophilic esophagitis.
Endoscopic Variceal Ligation Early Rebleeding Leads to Increased Mortality Risk
Time to rebleeding was a significant predictor of mortality risk following an endoscopic variceal ligation procedure.
Periodontal Disease, Tooth Loss Linked to Esophageal, Gastric Cancer
Periodontal disease and tooth loss, indicative of oral microbial dysbiosis, are associated with esophageal and gastric adenocarcinoma.
PPI Use and Dementia Development: Is There a Link?
PPIs are frequently used off-label and are easily accessible as over-the-counter products, contributing to the potential for adverse events or drug-drug interactions.
Improving Outcomes of Endoscopic Cricopharyngeal Myotomy in Zenker Diverticulum
A team of investigators assessed the ability of the intraprocedural functional lumen imaging probe to measure cricopharyngeal distensibility in patients undergoing endoscopy cricopharyngeal myotomy for Zenker diverticulum.
Routine Esophagram Following Peroral Endoscopic Myotomy does Not Reliably Identify Adverse Events
Post-procedural esophagram may be insufficient to diagnose serious adverse events in patients who underwent peroral endoscopic myotomy (POEM).
Sarcopenia a Prognostic Factor for Overall Survival in Men With Esophageal Carcinoma Treated with CRT
High sarcopenia levels appear to be negatively associated with overall survival in male patients with esophageal carcinoma treated with upfront chemoradiotherapy.
EsoFLIP-330 Safe for Treating Esophageal Motility Disorders
Use of a 30 mm hydrostatic balloon dilator (EsoFLIP-330) was safe in treating patients with esophageal motility disorders and was most effective in those with achalasia.
After Atrial Fibrillation, Oral Anticoagulants Increase Gastrointestinal Cancer Risk
Patients treated with non-vitamin K antagonist oral anticoagulants (NOACs) following atrial fibrillation were more likely to develop gastrointestinal bleeding and malignancies.
Proton Pump Inhibitors May Up Death Risk in Kidney Transplant Recipients
In a study of kidney transplant recipients, PPI users had an almost 2-fold increased risk of mortality compared with nonusers.
Opdivo Approved for Advanced Esophageal Squamous Cell Carcinoma
The FDA has approved Opdivo® (nivolumab; Bristol Myers Squibb) for the treatment of patients with unresectable advanced, recurrent or metastatic esophageal squamous cell carcinoma (ESCC) after prior fluoropyrimidine- and platinum-based chemotherapy.
Clinical, Anatomic Improvements With Dupilumab in Eosinophilic Esophagitis Study
Dupilumab was associated with clinical and anatomic improvements in patients with eosinophilic esophagitis, according to results from a pivotal phase 3 study.
Prevalence of Pediatric Eosinophilic Esophagitis in Medicaid Beneficiaries Lower in Impoverished, Rural Areas
The prevalence of pediatric eosinophilic esophagitis (EoE) may be lower among children living in impoverished areas compared with others.
Guidelines Issued for Managing Eosinophilic Esophagitis
Proton pump inhibition therapy is suggested over no treatment for patients with symptomatic esophageal eosinophilia.
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