Edema:

Indications for ACETAZOLAMIDE INJECTION:

Edema.

Adult Dosage:

Give by IV inj. Edema: give 1–2 days on, 1 day off. 250mg–375mg once daily. CHF: 250–375mg once daily in the AM. Acute high altitude sickness: see literature.

Children Dosage:

Not recommended.

ACETAZOLAMIDE INJECTION Contraindications:

Hypokalemia. Hyponatremia. Severe renal, hepatic, or adrenocortical impairment. Hyperchloremic acidosis. Cirrhosis. Chronic noncongestive angle-closure glaucoma. Sulfonamide allergy.

ACETAZOLAMIDE INJECTION Warnings/Precautions:

Respiratory impairment. Renal calcium calculi. Diabetes. Gout. Monitor blood and electrolytes. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

ACETAZOLAMIDE INJECTION Classification:

Carbonic anhydrase inhibitor.

ACETAZOLAMIDE INJECTION Interactions:

Inhibits renal excretion of basic drugs and promotes excretion of acidic drugs. May increase toxicity of salicylates (acidosis), folic acid antagonists. Hypokalemia with corticosteroids, potassium wasting diuretics. Monitor phenytoin, primidone, antihyperglycemics, quinidine, lithium, cyclosporine. Antagonizes methenamine.

Adverse Reactions:

Anorexia, drowsiness, confusion, malaise, depression, GI distress, paresthesias, tinnitus, acidosis, initial hypokalemia, hyperuricemia, transient myopia; renal calculi, nephrotoxicity, hepatic dysfunction, blood dyscrasias, rash, fever, photosensitivity (rare).

Note:

Formerly known under the brand name Diamox.

How Supplied:

Contact supplier.