Crohn Disease

Latest Articles

Validation of Lémann Index Assessing Bowel Damage in Patients With Crohn Disease

By

Bradley van Paridon

Investigators aimed to evaluate and update the Lémann index for the assessment of cumulative bowel damage in patients with Crohn disease.

Microscopic Colitis: Is Vedolizumab An Option?

By

C. Andrew Kistler, MD, PharmD

Due to the relatively high relapse rate and need for additional therapies, current research is being done on the use of Vedolizumab for the treatment of microscopic colitis.

Studies Support Transmural Healing as a Relevant Treatment Target in Crohn Disease

By

Brandon May

Investigators performed a systematic review to examine the varying definitions of transmural healing and assess its impact on CD-related outcomes.

Specific Carbohydrate Diet and Mediterranean Diet Lead to Similar Symptom Remission in Crohn Disease

By

Brandon May

Researchers compared the effectiveness of the specific carbohydrate diet with the Mediterranean diet for the management of Crohn disease symptoms.

Perianal Crohn Disease Is a Strong Predictor of a Complicated Disease Course

By

Virginia A. Schad, PharmD, RPh

Researchers evaluated perianal involvement in patients with CD and compared disease course in those with severe vs non-severe perianal CD.

Ustekinumab Shows Safety and Efficacy in Crohn Disease

By

Vincent Soreca

Researchers aimed to evaluate the long-term safety and efficacy of ustekinumab in a cohort of patients with Crohn disease with a follow-up of 2 years.

Vedolizumab Shows Better Safety Profile Compared With Anti-Tumor Necrosis Factor-α in IBD

By

Vincent Soreca

Researchers compared the clinical effectiveness and safety profiles of vedolizumab and anti-TNFα agents in biologic-naïve adult patients with ulcerative colitis and Crohn disease.

Diets Compared for Mild-to-Moderate Crohn Disease in Adults

The specific carbohydrate diet is not superior to the Mediterranean diet for the remission of symptoms in adults with mild-to-moderate Crohn disease.

AGA Issues Recommendations for Moderate-to-Severe Crohn Disease

In clinical practice guidelines from the American Gastroenterological Association (AGA) published in the June 1 issue of Gastroenterology, recommendations are presented for the management of moderate-to-severe luminal and fistulizing Crohn disease (CD) in adult outpatients.

Inflammatory Bowel Disease and Inflammatory Dermatologic Condition Comorbidities: A Distinct Subgroup of IBD Patients

By

Jessica Nye, PhD

Researchers evaluated the prevalence and severity of dermatologic inflammatory conditions in patients with IBD.

Novel Probiotic Combination for the Treatment of Crohn Disease

By

Emily Pond

Investigators analyzed the effects of a novel probiotic supplement on Crohn disease-like ileitis in murine models.

Vedolizumab Therapy More Effective in Certain Crohn Disease Subpopulations

By

Kate Shanaghan

Investigators aimed to identify subpopulations of patients with Crohn Disease in whom vedolizumab had greater success at achieving clinical remission than anti-TNFα.

Diet-Gut Microbiome Associations and Patients With Intestinal Disease

By

Virginia A. Schad, PharmD, RPh

Researchers studied the interactions between diet, gut microbiota, and their functional ability to induce intestinal inflammation.

Anti-Tumor Necrosis Factor Therapy Associated with Reduced Mortality in IBD

By

Vincent Soreca

Researchers aimed to examine the association of anti-TNF with reduced mortality relative to prolonged corticosteroid use in a cohort of veterans with IBD.

Treat-to-Target Strategy May Aid Ustekinumab Dosing Decisions in Crohn Disease

By

Colby Stong

Researchers compared use of a treat-to-target strategy vs standard of care in patients with Crohn disease treated with ustekinumab.

COVID-19 and IBD: Impact of Disease State and Biologics

By

C. Andrew Kistler, MD, PharmD

In patients with IBD, management of immunosuppressive regimens, as well as safety and efficacy of vaccines, has raised many questions during the COVID-19 pandemic.

Modified Multiplier of the Simple Endoscopic Score for Crohn Disease Shows Promise for Predicting the Achievement of Endoscopic Remission

By

Vincent Soreca

Researchers sought to validate a MM-SES-CD, which predicts the achievement of ER while on active therapy by taking into consideration each individual parameter’s prognostic value.

Marijuana and IBD: Challenging Decisions

By

C. Andrew Kistler, MD, PharmD

Though patient use of cannabinoids for the treatment of IBD has increased, clinical decision making on whether to formally recommend it as treatment remains difficult.

Fecal DPP-4 Level May Be Biomarker for Inflammatory Bowel Disease

By

Colby Stong

Researchers aimed to better elucidate the role of fDPP-4 levels as a biomarker of IBD activity and to correlate it with certain clinical parameters.

Study Explores Links Between Diet, Gut Microbiome, and Inflammation

Diet directly impacts the gut microbiome, which directly affects inflammatory responses in the gut.