Crohn Disease

Latest Articles

Dual Biologic Therapy in Crohn’s Disease: A New Treatment Paradigm?

By

Andy Kistler, MD, PharmD

There is significant interest in optimizing medical treatments of Crohn’s disease (CD) in hopes of preventing complications and the need for surgery.

Volatile Organic Compounds in the Stool: Markers of Inflammatory Bowel Disease

By

Jessica Nye, PhD

Measurement of fecal volatile organic compounds (VOC) was effective in identifying inflammatory bowel disease (IBD) biomarkers, but not for monitoring disease activity.

Associations Between Gastrointestinal Infection and New-Onset IBD

By

Dibash Kumar Das, PhD

Certain enteric pathogens are associated with higher risk of incident inflammatory bowel disease, while others are could be protective.

Infliximab Trough Levels Correlated with Remission in Luminal Crohn’s Disease

By

Jessica Nye, PhD

Higher infliximab trough levels were associated with clinical and endoscopic remission in patients with Crohn disease (CD), according to a substudy.

Adalimumab Effective in Managing IBD Symptoms in Patients with COVID-19

By

Dibash Kumar Das, PhD

Adalimumab, an anti-Tumor Necrosis Factor alpha (TNFα) antibody, may be effective in managing inflammatory bowel disease symptoms in patients with COVID-19.

Remission Rates Not Dependent on Control Strategy in Early Crohn Disease

By

Jessica Nye, PhD

An international team of investigators conducted a follow-up to the CALM study to assess the impact of early disease remission in individuals with Crohn disease.

Bacteremia Risk Higher in Older Patients Hospitalized With IBD

Older age is associated with an increased risk for bacteremia in hospitalized patients with inflammatory bowel disease.

Early Deep Remission of Crohn Disease Tied to Better Outcomes

Deep early remission of Crohn disease is associated with a significant decrease in long-term adverse effects.

Novel Serum Biomarker Panel Predicts Crohn Disease Diagnosis

By

Lauren Dembeck, PhD

A panel of serum biomarkers was found to identify patients who will develop Crohn disease up to 5 years before diagnosis.

Case Report: Autoimmune Encephalitis in Comorbid Crohn Disease and Ankylosing Spondylitis

By

Meghna Rao

In this case study presented at ACTRIMS 2020, researchers reported on data from a patient with Crohn disease and ankylosing spondylitis who developed autoimmune encephalitis while receiving infliximab.

Adolescent IBD: Medication and General Health Management Considerations

By

Gastroenterology Advisor Contributing Writer

This review examines the unique manifestations of inflammatory bowel disease (such as growth and pubertal delay), health maintenance issues, and treatment considerations in the adolescent.

Guidance Issued for Food Intake in Inflammatory Bowel Disease

There is insufficient evidence for recommending specific changes or restrictions of intake of fruit and vegetables in ulcerative colitis.

Pain in IBD Associated With Cognitive and Behavioral Factors

By

Jessica Nye, PhD

Emotions, cognitions, and behaviors are significantly associated with pain severity and pain-related interference in IBD, including pain-specific cognitions and behaviors.

General Dysfunctional Thinking Worsens Anxiety, Depression in IBD

By

Emily Pond

The study examined the importance of confronting general dysfunctional beliefs, particularly notions of low self-efficacy and failure, in short-term therapy for patients with IBD.

Inflammatory Bowel Disease Is an Independent Risk Factor for Post-Discharge VTE

By

Jessica Nye, PhD

An inflammatory bowel disease diagnosis conferred an increased risk for venous thromboembolism; however, in surgical patients, ulcerative colitis but not Crohn disease was responsible for the elevated risk.

IBD, Hidradenitis Suppurativa May Be Linked

There appears to be a link between hidradenitis suppurativa and inflammatory bowel disease.

Incidence of Osteoporosis Significantly Higher in IBD

By

Jessica Nye, PhD

Incidence of osteoporosis is significantly increased in patients with inflammatory bowel disease.

IBD May Increase Chronic Kidney Disease Risk

By

Natasha Persaud

The risk of CKD in patients with inflammatory bowel disease is highest among young individuals.

The Efficacy of Cannabinoids and Opioids in Inflammatory Bowel Diseases

By

Gastroenterology Advisor Contributing Writer

In recent years, a number of preclinical models have shown that cannabinoids may be highly effective at improving inflammation and, therefore, may be a potential treatment for inflammatory bowel diseases.

Crohn Disease Response, Remission Demonstrated After 2 Doses of Ustekinumab

By

Brian Park, PharmD

Janssen announced interim data from the phase 3b STARDUST study of ustekinumab for the treatment of moderately to severely active Crohn disease.