AGA: Gastrointestinal Innovation at the Forefront of Clinicians’ Minds
AGA Center for GI Innovation and Technology hosted “Colorectal Cancer Screening and Surveillance: Role of Emerging Technology and Innovation to Improve Outcomes.”
Colorectal Neoplasia
COLORECTAL NEOPLASIA
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Indefinite Dysplasia in IBD is Independently Associated With Advanced Colorectal Neoplasia
In patients with inflammatory bowel diseases (IBD) who underwent colonoscopic surveillance for colorectal neoplasia (CRN), indefinite dysplasia was independently associated with a significant increase in advanced CRN risk.
Cancer Screening Rates Lower Among Women With Diabetes
Women with diabetes have lower rates of breast, cervical, and colorectal cancer screening compared with women without diabetes.
Expert Q&A: Discussing Recent ACP Guidance on CRC Screening, Reconciling Differences Across Other Screening Guidelines
Gastroenterology Advisor spoke to Dr. Robert McLean, President of the American College of Physicians (ACP), and Dr. Timothy Wilt, Chair of ACP’s Clinical Guidelines Committee to address several of these questions from the Colorectal Cancer Screening Guidance Statement.
Personal Colorectal Cancer Risk Should Drive Screening
Using the GRADE system to review new evidence, a panel issued weak recommendations for colorectal cancer screening options based on estimated 15-year individual risk.
ASA: Enhanced Recovery Program Cuts Opioid Use After Colorectal Surgery
Colorectal surgery patients treated as part of an enhanced recovery after surgery (ERAS) program have less pain and use nearly half as many opioids as pre-ERAS patients.
Prediagnostic Colonoscopy Cuts Colorectal Cancer Death Risk
The risk for colorectal cancer death drops with an increasing number of prediagnostic colonoscopies, largely due to fewer advanced cancers at time of diagnosis.
Triplet Treatment Increases Survival in BRAF V600E-Mutated Colorectal Cancer
A triplet combination of therapies results in significantly longer overall survival and a higher response rate than standard therapy in patients with metastatic colorectal cancer with the BRAF V600E mutation.
Low Cancer Suspicion Tied to Delay in CRC Referral in Primary Care
Delay in referral for colorectal cancer (CRC) in primary care is associated with low cancer suspicion.
Will More Colorectal Cancer Testing Options Increase Screening Rates?
Investigators studied whether colorectal cancer screening rates are influenced by how test options are presented to patients.
PDE5 Inhibition and Colorectal Cancer Risk: Is There a Link?
PDE5 inhibitor use was associated with a 35% decreased risk for CRC in male patients with a history of a benign colorectal neoplasm, and the decrease was associated with increasing cumulative dose of PDE5 inhibitors.
Association Between Oral Antibiotics and Risk for Colorectal Cancers: A Matched Case-Control Study
The researchers concluded that the use of oral antibiotics was associated with colorectal cancer, but the effect size and pattern of risk varied by anatomical location in the colorectum.
High-Intensity Surveillance Favored Over Low-Intensity After Colorectal Adenoma Removal
High-intensity surveillance after removal of adenoma provides modest incremental clinical benefits at an acceptable cost over return to routine screening or low-intensity surveillance and that current US recommendations for 5-year and 3-year surveillance following LRA removal and HRA removal, respectively, remain reasonable.
High-Intensity Surveillance of Colorectal Adenomas Modeled
For patients with colorectal adenomas, high-intensity surveillance could provide modest benefits over low-intensity surveillance, at an acceptable cost.
Risk of Cancer in Individuals With Lynch Syndrome Can Vary With Age, Gender, and MMR Gene Alteration
According to this prospective study, the lifetime risk of cancer in men with a pathogenic germline MSH6 alteration is relatively low.
Updated ESMO Recommendations for Hereditary Gastrointestinal Cancers
Recommendations were developed and graded in accordance with the ESMO Clinical Practice Guidelines and subjected to an anonymous peer-review process.
Patients, Caregivers Share High Level of Agreement in Assessments of Colorectal Cancer Care
Survey results show level of concordance between patients with CRC and their caregivers when rating care quality. The survey also measured whether clinical or demographic factors influenced the agreement between patient-caregiver pairs.
Incidence of Colorectal Cancer Increased in Younger Adults Worldwide
The uptick in early-onset disease began in the mid-1990s among most high-income countries with long-term data. In younger adults, the steepest increases were seen in South Korea and New Zealand (average annual percent change, 4.2 and 4.0, respectively).
Tumor Seeding During Colonoscopy May Cause Subsequent Metachronous CRC
Primary tumor cells may be seeded in damaged mucosa during colonoscopy to biopsy a primary tumor, increasing the risk for metachronous CRC.
Physical Activity, Overall Survival Not Linked in Metastatic CRC
For patients with advanced/metastatic colorectal cancer (mCRC), greater total physical activity is not associated with longer overall survival, but it may prolong progression-free survival and lower the risk for treatment-related toxicities.
Costs of Reusable Colonoscopes Vary Based on Center Volume
The cost per colonoscopy, including purchase, maintenance, and reprocessing costs, varies from $188.64 to $501.16, with higher costs at low-volume centers.
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