Chronic Liver Disease

Latest News

Excessive Drinking Responsible for 255 Deaths Per Day in US

Excessive drinking was responsible for an average of 255 deaths per day in the United States during 2011 to 2015.

Fecal Microbiota Transplantation for Recurrent Clostridioides difficile in Cirrhosis

By

Sweta Gupta

A team of investigators sought to investigate the rate of resolution of Clostridioides difficile infection as well as safety associated with fecal microbiota transplantation in patients with liver cirrhosis.

Early Rebleeding Following Endoscopic Variceal Ligation Associated With Increased Mortality Risk

By

Jessica Nye, PhD

Time to rebleeding was a significant predictor of mortality risk following an endoscopic variceal ligation procedure.

Women at Lower Risk for Nonalcoholic Fatty Liver Disease But at Greater Risk for Progression

By

Jessica Nye, PhD

A systematic review and meta-analysis of observational studies was conducted to assess the prevalence of nonalcoholic fatty liver disease in the general population.

Updates on NAFLD: Is FMT the Treatment of the Future?

By

C. Andrew Kistler, MD, PharmD

As the role of the gut microbiome in nonalcoholic fatty liver disease is explored, research has turned to fecal microbiota transplantation as a potential treatment option.

Clinical Hold Lifted on Seladelpar for Chronic Liver Diseases

By

Brian Park, PharmD

The FDA has lifted the clinical hold on 3 Investigational New Drug applications evaluating seladelpar (CymaBay Therapeutics) for the treatment of non-alcoholic steatohepatitis, primary biliary cholangitis and primary sclerosing cholangitis.

CDC Guidance Issued for Testing, Management of Healthcare Personnel Exposed to Hepatitis C

Recommendations are presented for testing and clinical management of health care personnel exposed to the hepatitis C virus in a US Centers for Disease Control and Prevention guidance report.

Routine Hepatitis C Testing at Federally Qualified Health Centers Would Be Cost-Effective

Routine hepatitis C virus testing at federally qualified health centers would be cost-effective and could improve outcomes for people with HCV infections.

Efficacy of Bundled HIV, HCV Testing for People With Substance Abuse Disorders Examined

By

Bradley van Paridon

By providing bundled HIV and HCV testing, substance use disorder treatment programs may create increased awareness of infection status among people with substance abuse disorders.

Elevated Liver Fibrosis Index Scores May Predict Poorer COVID-19 Outcomes

By

Emily Pond

A team of investigators assessed outcomes associated with advanced liver fibrosis in patients with COVID-19 infection.

Pre-Existing Cirrhosis Linked to Higher COVID-19 Mortality

By

Jessica Nye, PhD

A team of investigators in Italy assessed outcomes in patients with both cirrhosis and COVID-19 infection.

Viral Exposure Signature Predicts Hepatocellular Carcinoma

A viral exposure signature can predict hepatocellular carcinoma (HCC) risk before clinical diagnosis among at-risk patients.

Failure to Control Oesophago-Gastric Variceal Bleeding Associated With Increased Mortality

By

Jessica Nye, PhD

Failure to control oesophago-gastric variceal bleeding in patients with acute-on-chronic liver failure resulted in increased mortality risk.

Small Case Series Describes Clinical Course of Patients With COVID-19 and Chronic HBV

By

Brandon May

Researchers found that no patients with concomitant COVID-19 and hepatitis B virus infection progressed to severe or critically ill status during hospitalization, but many had abnormal liver function tests on admission.

Tenofovir Disoproxil Fumarate Associated With Higher Rates of Elastographic Reversion in Patients With Hepatitis B

By

Jessica Nye, PhD

TDF therapy resulted in greater rates of elastographic reversion of cirrhosis in patients with chronic hepatitis B at year 5 compared with entecavir.

Subclinical Hypothyroidism in NAFLD Is Associated With All-Cause and Cardiovascular Mortality

By

Rose Reeb

Low thyroid function is associated with nonalcoholic fatty liver disease and predicted all-cause and cardiovascular mortality in this population.

Detection of Hypervirulent Klebsiella pneumoniae Strains in New York City

By

Bradley van Paridon

A team of researchers conducted surveillance at a New York City hospital to assess the prevalence K pneumoniae.

ISHEN Releases Consensus Statement on Unanswered Questions in Hepatic Encephalopathy Management

By

Brandon May

The International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) has published consensus statements on the management of HE.

Acute Liver Injury Prevalent in Patients with COVID-19

By

Jessica Nye, PhD

Researchers observed the presence of acute liver injury caused by COVID-19 in patients at multiple hospitals in China.

Risk for Maternal, Neonatal Complications Increased With NAFLD

Women with non-alcoholic fatty liver disease have increased risks for maternal and neonatal complications.