Chronic Liver Disease

Latest News

Alcohol Abstinence Increased Among Young Adults From 2002 to 2018

Alcohol use decreased, but marijuana use and co-use of marijuana and alcohol increased from 2002 to 2018 in US young adults.

COVID-19 Diagnosis Increases Hospitalization Risk in People With Liver Transplant

By

Colby Stong

Although hospitalization risk was higher, mortality, thrombosis, and ICU admission risks were the same in patients with and without liver transplants.

Premature Deaths From Alcoholic Liver Disease Trend Upward Over 2 Decades

By

Emily Pond

Study data have identified an upward trend in premature deaths associated with alcoholic liver disease by sex and race.

Three Scientists Share Nobel Prize for Hepatitis C Research

Two US researchers and a British scientist have been awarded the 2020 Nobel Prize in physiology or medicine for major contributions to the fight against blood-borne hepatitis.

Liver Resection May Close Racial Gap in Overall Survival Among Patients With Colorectal Liver Metastasis

By

Emily Pond

Overall survival is significantly lower among Black patients with colorectal liver metastases compared with other races.

Gut Microbiome in Cirrhosis Linked to Acute-on-Chronic Liver Failure

By

Virginia A. Schad, PharmD, RPh

Researchers analyzed the relationship between an altered gut microbiome and complications of cirrhosis and survival and sought to determine its effect on disease progression and prognosis.

CPAP Therapy Does Not Appear to Improve Nonalcoholic Fatty Liver Disease in OSA

By

Sheila Jacobs

The use of CPAP alone does not appear to improve hepatic steatosis and fibrosis in patients with nonalcoholic fatty liver disease and obstructive sleep apnea.

Hepatosplenic T-cell Lymphoma: Recent Progress and Future Considerations

By

Lauren Dembeck, PhD

Researchers reviewed the clinical/pathologic aspects of HSTCL and summarized the latest molecular studies and potential novel therapeutic targets.

FDA Rejects Terlipressin NDA for Hepatorenal Syndrome Type 1

By

Brian Park, PharmD

In July 2020, the FDA Cardiovascular and Renal Drugs Advisory Committee narrowly voted 8 to 7 in favor of the approval of terlipressin for HRS-1.

Serum Albumin Levels at 1 Month of Human Albumin Treatment Predict Outcomes

By

Jessica Nye, PhD

Could one month on treatment albuminemia predict survival and guide treatment decisions? Investigators find out.

FDA Fast Tracks SSAO Inhibitor for Nonalcoholic Steatohepatitis

By

Brian Park, PharmD

TERN-201 is a highly-selective semicarbazide-sensitive amino oxidase inhibitor.

Sex-Disparities Exist in Liver Transplant Allocation

Women are more likely than men to die waiting for a liver transplant.

Systemic Inflammation in COVID-19 Could Be Responsible for Liver Damage

By

Emily Pond

In patients with COVID-19, hepatic injury was associated with elevated levels of IL-6, CRP, ferritin, and lactate dehydrogenase.

Simultaneous Splenectomy Selectively Suggested in Living Donor Liver Transplantation

By

Colby Stong

Simultaneous splenectomy may prevent small-for-size graft syndrome in adults with a living donor liver transplantation.

Novel Biomarker Panel May Allow for Noninvasive Non-Alcoholic Steatohepatitis Diagnosis

By

Emily Pond

The NIS4 biomarker panel may provide a means for clinicians to avoid unnecessary liver biopsies in patients at low risk for NASH.

Sex Differences in Liver Transplant Candidates With Portopulmonary Hypertension

By

Sheila Jacobs

Female candidates for liver transplant who have portopulmonary hypertension have higher pulmonary vascular resistance, lower Model for End-Stage Liver Disease scores, and are more likely to have autoimmune liver disease, compared with male candidates.

Safety, Efficacy of 8-Week Glecaprevir/Pibrentasvir for Treatment-Naive HCV Examined

By

Bradley van Paridon

Eight weeks of treatment with glecaprevir/pibrentasvir is both efficacious and well tolerated in treatment-naive patients with HCV.

ASCO Issues Provisional Opinion Update on Hepatitis B Screening

By

Leah Lawrence

ASCO recommends that patients with newly diagnosed cancer slated to receive systemic anticancer meds be tested for HBV by 3 tests prior to starting therapy.

Updated CDC Guidance for Healthcare Personnel With Potential Exposure to HCV

By

Zahra Masoud

New CDC guidelines recommend a test-and-treat approach for healthcare personnel who may have been exposed to acute hepatitis C virus infection at work.

Improved Outcomes With Cabozantinib in HCC Across All Baseline AFP Levels

By

Andrea S. Blevins Primeau, PhD, MBA

Cabozantinib prolonged survival compared with placebo regardless of baseline AFP levels. Lower baseline AFP levels associated with the longest survival.