Baraclude Long-Term Saftey Data Included in Updated Labeling
Baraclude was not significantly associated with an increased risk of malignant neoplasms compared to other standard-of-care HBV nucleos(t)ides.
Chronic Liver Disease
CHRONIC LIVER DISEASE
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Chemical Analysis Links Kratom to Cases of Severe Liver Injury
Liver injury episodes due to kratom (Mitragyna speciosa) are increasing in the United States, and chemical analysis can confirm the presence of this botanical in herbal and dietary supplements linked to cases of severe liver injury.
Two-Dose Versus Three-Dose HBV Vaccine Assessed in Older Patients with T2DM
For older patients with type 2 diabetes mellitus, higher levels of seroprotection against the hepatitis B virus were obtained following the receipt of the 2-dose vaccine vs the 3-dose vaccine.
Highlighting the Gaps in Understanding Hepatitis E
Researchers suggest that the hepatitis E virus remains a worldwide threat because more needs to be investigated about its transmission.
Predictors of Transmission Risk in Hepatitis C
Investigators found that young age, high HCV viral load, and HCV/HIV co-infection were the factors associated with an increased transmission risk.
Lower Simvastatin Dose Preferred in Treatment of Decompensated Cirrhosis
As a part of the LIVERHOPE project, researchers evaluated the safety of 2 different simvastatin doses in combination with rifaximin vs placebo in patients with decompensated cirrhosis.
Entecavir for Treatment of HBV in Patients With Renal Dysfunction
Researchers found data that showed entecavir is safe in the treatment of hepatitis B virus in patients who are undergoing hemodialysis.
Investigational Ubrogepant Does Not Confer Hepatotoxicity in Healthy Individuals
Investigators aimed to evaluate the safety and tolerability of ubrogepant, focusing on hepatic safety, when administered intermittently with high-frequency dosing in healthy participants.
Early Antiviral Therapy Reduces HBsAg in Infantile Hepatitis B Infection
Researchers found data that showed early initiation of antiviral therapy with lamivudine in infants with hepatitis B caused a rapid loss of HBsAg.
Sofosbuvir/Velpatasvir/Voxilaprevir as Rescue Therapy for Those Failing DAA Therapy in HCV
Researchers found data that showed in patients with hepatitis C, the presence of resistance-associated substitutions did not change the sustained viral response after treatment failure with other direct-acting-antivirals with the combination of sofosbuvir, velpatasvir, and voxilaprevir.
Telbivudine and Tenofovir May Reduce Vertical Transmission of HBV
Researchers found data that showed in pregnant women with hepatitis B, the antiviral medications telbivudine and tenofovir disoproxil fumarate were safe, effective, and well tolerated, while reducing transmission of hepatitis B from mother to child during the perinatal period.
Decreasing Hepatitis C Infection Rates: Considerations for a Vaccine
Researchers explore factors that surround creating a vaccine to combat hepatitis C virus infection.
Chronic HCV Infection and Cerebrovascular Disease Risk
Researchers found data that showed chronic hepatitis C virus infection and associated carotid intima-media thickness and plaque are predictors for cerebrovascular disease.
Liver Enzymes in Children, Adolescents Are Affected by Obesity
Obesity was found to be associated with elevated markers of liver damage in children and adolescents.
Investigational Farnesoid X Receptor Agonist Gets Fast Track Status for NASH
The FDA has granted Fast Track designation to TERN-101 (Terns Pharmaceuticals) for the treatment of non-alcoholic steatohepatitis.
Hypoglycemia Risk May Be Lower With Liver-Targeted Rapid-Acting Insulin Formulation
Hepatic-directed vesicle insulin, a novel liver-targeted rapid-acting insulin formulation for type 1 diabetes, is noninferior to insulin lispro for improvement of HbA1c and is associated with a lower hypoglycemia risk in some patients.
Isotretinoin Does Not Increase Liver Enzyme Elevations in Patients With Severe Acne
Acne patients receiving isotretinoin may not need continued testing when experiencing low-grade liver enzyme abnormalities, as most mild elevations do not worsen.
Opportunities to Improve Hepatitis A and Hepatitis B Vaccination Coverage
Two studies on hepatitis A and hepatitis B vaccination highlight opportunities to improve coverage of ≥2 doses of hepatitis A vaccine in children and hepatitis B vaccine series completion in adults.
Demographic Shifts in Hepatitis E and Hepatitis C Infection
Hepatitis E seropositivity is higher in older adults and may represent an increased exposure risk over time; in contrast, the opioid crisis has caused a demographic shift in hepatitis C infection, which is now a predominately millennial disease.
Higher Virologic Response to DAAs in HCV, HBV Coinfection vs Monoinfection
Direct-acting antiviral agents for treatment of hepatitis C virus may have higher sustained virologic responses in people coinfected with hepatitis B and hepatitis C viruses.
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