Lauren Dembeck, PhD

Researchers reviewed the clinical/pathologic aspects of HSTCL and summarized the latest molecular studies and potential novel therapeutic targets.

Children with inflammatory bowel diseases (IBD) show a 2-fold increase in cancer incidence during adulthood, according to a study published in Gastroenterology.

The authors of a published viewpoint report that patients with IBD do not appear to be at increased risk for SARS-CoV-2 infection.

An international, multicenter study was conducted to assess the long-term safety and efficacy of an experimental monoclonal antibody against interleukin-13 in patients with eosinophilic esophagitis.

Clinical remission was more likely with vedolizumab vs infliximab in UC after failure of initial anti-TNF agent.

Advanced non-alcoholic steatohepatitis may be linked to low serum lipoprotein(a) levels

Investigators from Germany conducted a population-based, case-control study to assess colorectal cancer risk.

A high prevalence of endoscopic and histologic disease activity was found in clinically quiescent ulcerative colitis.

European guidelines for colorectal cancer screening advise that the interval cancer rate be expressed as a proportion of the background incidence rate.

As bariatric surgery has been found to be associated with reduced cancer risk in women with obesity, investigators sought to determine if the potential exists for an effect on risk for colorectal cancer.

A panel of serum biomarkers was found to identify patients who will develop Crohn disease up to 5 years before diagnosis.

The prevalence of diverticulosis has been increasing, and research has demonstrated an increased risk of underlying colorectal cancer in this population.

As the process of endoscopy presents an increased risk for the transmission of infection, effective mitigation measures are paramount for preventing further dissemination of coronavirus in this setting.

Risks of surgery, hospitalization, and corticosteroid exposure in elderly-onset IBD was similar to those in adult-onset IBD, whereas immunomodulators and biologic agents were used less frequently.

Upadacitinib was effective in inducing remission in patients with moderate to severe ulcerative colitis.

Artificial intelligence assistance system significantly increased the accuracy of colorectal polyp analysis by novice endoscopists, who achieved near-expert levels of accuracy without extra training.

The researchers sought to develop a deep neural network system for consistent, objective, and real-time analysis of endoscopic images from patients with ulcerative colitis.

Ileal pouch–anal anastomosis surgery as treatment for ulcerative colitis met the expectations of cure of the disease, maintaining adequate long-term intestinal functionality associated with a good quality of life.

Prospective studies are needed to validate the Ulcerative Colitis Response Index algorithm as a surrogate marker panel for mucosal healing, with the ultimate goal being to avoid unnecessary endoscopic evaluations.

The prevalence of H pylori infection continues to fall in the general population with only 16% of all gastric and 25% of all duodenal patients with ulcer harboring H pylori.

Natural genetic variants in a calcium-selective ion channel gene, TRPV6, appear to influence early-onset chronic pancreatitis.

In-hospital mortality rates among patients requiring mechanical ventilation were not significantly different when comparing 2 stress ulcer prophylaxis strategies: proton pump inhibitors vs histamine-2 receptor blockers.

The aim of this real-life study was to evaluate the effectiveness and predictors of response of adalimumab in a large Swedish cohort of patients with ulcerative colitis.

A mechanism was identified through which a Western diet and antibiotic use may be able to promote tumorigenesis by colon cancer cells after curative resection.

Increased neutrophils in the colonic mucosa of patients with UC were associated with increased use of systemic corticosteroids, colectomy, and hospitalization during 3 years of follow-up.

Patients with female eosinophilic esophagitis considering pregnancy should be informed that to date, no increased maternal and fetal risk was observed in pregnant patients with EoE on and off EoE-specific medication.

In this prospective study of patients with biopsy-proven NAFLD, daily aspirin use was associated with less severe histologic features of NAFLD and NASH, and with lower risk for progression to advanced fibrosis.

Proactive monitoring of adalimumab trough concentrations in children was associated with higher corticosteroid-free sustained remission and biologic remission rates compared with reactive monitoring in pediatric patients with Crohn disease.

The abundance of particular gut microbes believed to regulate immune response were reduced in fecal samples from participants on the low-FODMAP diet compared with those on the control diet.

The researchers concluded that this is the first study to investigate the mucosa-associated gut microbiome in an adult population-based cohort and that no distinct microbial signature was observed in IBS.