John I. Gallin, Author at Gastroenterology Advisor

John I. Gallin

All articles by John I. Gallin

Toll-like receptor signaling defects

Toll-like receptor signaling defects What every physician needs to know: This chapter discusses Toll-like receptor signaling defects (interleukin-1 receptor-associated kinase 4 [IRAK-4], myeloid differentiation primary response gene [88] [MYD88], NF-kappa-B essential modulator [NEMO]). Signal transduction both to generate and to perpetuate inflammation requires the activation of nuclear factor kappa B (NFkB). Therefore, defects along this…

Disorders of neutrophils: GATA2 Deficiency (MonoMAC2 DCML, Emberger, familial AML/MDS, classical NK cell deficiency)

Disorders of neutrophils: GATA2 Deficiency (also known as MonoMAC, DCML, Emberger, familial AML/MDS, classical NK cell deficiency) What every physician needs to know: GATA2 is a critical transcription factor in early hematopoietic ontogeny. Haploinsufficiency for GATA2 causes conditions ranging from deafness to lymphedema to acute myelogenous leukemia to disseminated mycobacterial infection, with ages of onset…

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