Albert La

At a Glance Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune syndrome associated with malignancies, such as small cell lung-cancer, as well as other diseases, including Sjögren’s syndrome, vitiligo, and thyroid disease. The presenting symptoms are fatigue and muscle weakness, especially of the proximal leg, with weak or absent muscle reflexes. In addition, patients often complain…

At a Glance Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized neuropathologically by a loss of upper motor neurons in the motor cortex and lower motor neurons in the anterior horn of the spinal cord. Clinically, ALS should be suspected in patients that present with painless focal muscle weakness and atrophy that progresses over…