Generic Version of Amitiza Now Available
The Company has begun shipping both the 8mcg and 24mcg capsules; the capsules are supplied in 60-count bottles.
Anorectal Disorders
ANORECTAL DISORDERS
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The Crohn’s Anal Fistula Quality of Life Scale: A Patient-Reported Outcome Measure
As Crohn disease perianal fistulas often do not respond to available treatments, researchers developed a patient-derived quality-of-life tool to evaluate the impact of the condition on patients.
RAPIDO Trial Supports New Standard of Care for Advanced Rectal Cancer
Short-course radiotherapy followed by chemotherapy and total mesorectal excision improved outcomes for patients with high-risk locally advanced rectal cancer.
Less Invasive Treatment Feasible for Early-Stage Rectal Cancer
High level of organ preservation, improved QoL seen with short-course radiotherapy followed by transanal endoscopic microsurgery
Pandemic-Related Delays in Cancer Screenings and Treatment Threaten Progress in Cancer Mortality Rates
If the current COVID-19 trends persist, the NCI estimates that the pandemic’s impact could threaten the trend of annually decreasing cancer mortality seen in the US since 1990.
Targeted Therapies, Immunotherapies, and Immunomodulators: A Quick Guide to Cancer Therapy
Sometimes the distinctions between cancer treatment groups are a little blurry. Here’s a guide to their definitions and origins.
Digital Manometry Device May Be Effective for Evaluating Anorectal Function in Patients With Constipation
Digital manometry provides similar pressure readings compared with the gold-standard high-resolution anorectal manometry in patients with chronic constipation and fecal incontinence.
Total Mesorectal Excision May Be Unnecessary for Small T2-T3 Low Rectal Cancer
Survival and recurrence rates were not significantly different between patients with low rectal cancer who were treated with either local or total mesorectal excision.
IAPWG Recommendations for Testing and Classification of Anorectal Function
These recommendations provides a much‐needed framework for clinicians performing and interpreting tests of anorectal function.
Incidence of Squamous Cell Carcinoma of the Anus Increasing
There has been an increase in the incidence of squamous cell carcinoma of the anus (SCCA) in the United States.
Recommendations and Criteria for Establishing a Stool Bank or FMT Center
Stool banks may guarantee reliable, timely and equitable access to fecal microbiota transplantation for patients and a traceable workflow that ensures safety and quality of procedures.
Fistula Relapse Risk in Perianal Crohn Disease Is Higher After Discontinuation of Anti-TNF
Discontinuation of anti–TNF therapy in patients with perianal Crohn disease may increase the risk for fistula relapse.
Factors Correlated to HRARM Findings in Chronic Constipation
In patients with chronic constipation, the most common form of anorectal dysfunction is Type 1 dyssynergic defecation.
Normative Values Established for Anorectal Neuropathy Using Novel TAMS
This study provides normative values for the bilateral lumbar and sacral-anorectal MEPs in healthy subject with no age or gender influence on rectal or anal MEP latency.
Interdisciplinary Group Treatment Effective for Pediatric Fecal Incontinence
An interdisciplinary group treatment for fecal incontinence in children (called “Poop group” by investigators) is a promising alternative for up to 60% of patients who fail to respond to standard care.
Men Less Knowledgeable About HPV, HPV Vaccination
Men are less knowledgeable than women about human papillomavirus (HPV), HPV vaccination, and the correlation between HPV and cancer.
Rectocele Associated With Anal Sphincter Function in Rectal Intussusception
This study demonstrated that a reduction in internal anal sphincter function was more common not only in patients with rectoanal intussusception, but also in those without rectocele.
New Index Developed For Assessment of Perianal Fistulas in Crohn Disease
MAGNIFI-CD has improved operating characteristics compared to other indices assessing MRI scans of perianal fistula activity in CD, and that the new index may be useful as an outcome measure in clinical trials investigating treatment for perianal fistulizing CD.
Baseline Urinary Dysfunction May Increase Following Rectal Cancer Treatment
Study concludes that few of the associated risk factors are modifiable and that clinicians should stress possible outcomes related to urinary dysfunction prior to patients receiving treatment for rectal cancer.
Comparing Long-Course Chemoradiation With Short-Course Radiation Therapy in Rectal Cancer
Early results from the Polish II study showed a significant improvement in OS for preoperative short-course RT/chemotherapy compared with long-term chemo-RT.
Naldemedine Therapy May Reduce Symptoms of Opioid-Induced Constipation
Researchers conducted a double-blind study to assess the effect of naldemedine therapy vs placebo in reducing symptoms associated with opioid-induced constipation.
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