The BLA submission is supported by data from the phase 2 POD1UM-202 study, which evaluated retifanlimab in patients with locally advanced or metastatic SCAC who progressed after platinum-based chemotherapy.
Researchers evaluated perianal involvement in patients with CD and compared disease course in those with severe vs non-severe perianal CD.
Researchers analyzed the relationship between adolescent simple sugar and sugar-sweetened beverages intake and the development of colorectal cancer.
While anal cancer is relatively uncommon in the general population, its incidence is substantially elevated in certain groups, including patients with HIV and certain autoimmune conditions.
The BLA is supported by data from the POD1UM-202 trial that evaluated retifanlimab in 94 adults with locally advanced or metastatic SCAC who progressed after platinum-based chemotherapy.
As Crohn disease perianal fistulas often do not respond to available treatments, researchers developed a patient-derived quality-of-life tool to evaluate the impact of the condition on patients.
The Company has begun shipping both the 8mcg and 24mcg capsules; the capsules are supplied in 60-count bottles.
Short-course radiotherapy followed by chemotherapy and total mesorectal excision improved outcomes for patients with high-risk locally advanced rectal cancer.
High level of organ preservation, improved QoL seen with short-course radiotherapy followed by transanal endoscopic microsurgery
If the current COVID-19 trends persist, the NCI estimates that the pandemic’s impact could threaten the trend of annually decreasing cancer mortality seen in the US since 1990.
Sometimes the distinctions between cancer treatment groups are a little blurry. Here’s a guide to their definitions and origins.
Digital manometry provides similar pressure readings compared with the gold-standard high-resolution anorectal manometry in patients with chronic constipation and fecal incontinence.
Survival and recurrence rates were not significantly different between patients with low rectal cancer who were treated with either local or total mesorectal excision.
These recommendations provides a much‐needed framework for clinicians performing and interpreting tests of anorectal function.
There has been an increase in the incidence of squamous cell carcinoma of the anus (SCCA) in the United States.
Stool banks may guarantee reliable, timely and equitable access to fecal microbiota transplantation for patients and a traceable workflow that ensures safety and quality of procedures.
Discontinuation of anti–TNF therapy in patients with perianal Crohn disease may increase the risk for fistula relapse.
In patients with chronic constipation, the most common form of anorectal dysfunction is Type 1 dyssynergic defecation.
This study provides normative values for the bilateral lumbar and sacral-anorectal MEPs in healthy subject with no age or gender influence on rectal or anal MEP latency.
An interdisciplinary group treatment for fecal incontinence in children (called “Poop group” by investigators) is a promising alternative for up to 60% of patients who fail to respond to standard care.