Laparoscopic Surgery Does Not Compromise Long-Term Survival Outcomes in Rectal Cancer
Researchers assessed the safety of laparoscopic surgery vs open surgery for rectal cancer using 10-year follow-up data.
Anorectal Disorders
ANORECTAL DISORDERS
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FDA Panel Votes to Defer Decision on Retifanlimab for Anal Cancer
The BLA submission is supported by data from the phase 2 POD1UM-202 study, which evaluated retifanlimab in patients with locally advanced or metastatic SCAC who progressed after platinum-based chemotherapy.
Perianal Crohn Disease Is a Strong Predictor of a Complicated Disease Course
Researchers evaluated perianal involvement in patients with CD and compared disease course in those with severe vs non-severe perianal CD.
High Consumption of Sugar During Adolescence Associated With Risk of Adenoma
Researchers analyzed the relationship between adolescent simple sugar and sugar-sweetened beverages intake and the development of colorectal cancer.
Lancet Authors Call for Improvement in Anal Cancer Screening Uptake
While anal cancer is relatively uncommon in the general population, its incidence is substantially elevated in certain groups, including patients with HIV and certain autoimmune conditions.
Retifanlimab Under Review for Anal Squamous Cell Carcinoma
The BLA is supported by data from the POD1UM-202 trial that evaluated retifanlimab in 94 adults with locally advanced or metastatic SCAC who progressed after platinum-based chemotherapy.
The Crohn’s Anal Fistula Quality of Life Scale: A Patient-Reported Outcome Measure
As Crohn disease perianal fistulas often do not respond to available treatments, researchers developed a patient-derived quality-of-life tool to evaluate the impact of the condition on patients.
Generic Version of Amitiza Now Available
The Company has begun shipping both the 8mcg and 24mcg capsules; the capsules are supplied in 60-count bottles.
RAPIDO Trial Supports New Standard of Care for Advanced Rectal Cancer
Short-course radiotherapy followed by chemotherapy and total mesorectal excision improved outcomes for patients with high-risk locally advanced rectal cancer.
Less Invasive Treatment Feasible for Early-Stage Rectal Cancer
High level of organ preservation, improved QoL seen with short-course radiotherapy followed by transanal endoscopic microsurgery
Pandemic-Related Delays in Cancer Screenings and Treatment Threaten Progress in Cancer Mortality Rates
If the current COVID-19 trends persist, the NCI estimates that the pandemic’s impact could threaten the trend of annually decreasing cancer mortality seen in the US since 1990.
Targeted Therapies, Immunotherapies, and Immunomodulators: A Quick Guide to Cancer Therapy
Sometimes the distinctions between cancer treatment groups are a little blurry. Here’s a guide to their definitions and origins.
Digital Manometry Device May Be Effective for Evaluating Anorectal Function in Patients With Constipation
Digital manometry provides similar pressure readings compared with the gold-standard high-resolution anorectal manometry in patients with chronic constipation and fecal incontinence.
Total Mesorectal Excision May Be Unnecessary for Small T2-T3 Low Rectal Cancer
Survival and recurrence rates were not significantly different between patients with low rectal cancer who were treated with either local or total mesorectal excision.
IAPWG Recommendations for Testing and Classification of Anorectal Function
These recommendations provides a much‐needed framework for clinicians performing and interpreting tests of anorectal function.
Incidence of Squamous Cell Carcinoma of the Anus Increasing
There has been an increase in the incidence of squamous cell carcinoma of the anus (SCCA) in the United States.
Recommendations and Criteria for Establishing a Stool Bank or FMT Center
Stool banks may guarantee reliable, timely and equitable access to fecal microbiota transplantation for patients and a traceable workflow that ensures safety and quality of procedures.
Fistula Relapse Risk in Perianal Crohn Disease Is Higher After Discontinuation of Anti-TNF
Discontinuation of anti–TNF therapy in patients with perianal Crohn disease may increase the risk for fistula relapse.
Factors Correlated to HRARM Findings in Chronic Constipation
In patients with chronic constipation, the most common form of anorectal dysfunction is Type 1 dyssynergic defecation.
Normative Values Established for Anorectal Neuropathy Using Novel TAMS
This study provides normative values for the bilateral lumbar and sacral-anorectal MEPs in healthy subject with no age or gender influence on rectal or anal MEP latency.
Interdisciplinary Group Treatment Effective for Pediatric Fecal Incontinence
An interdisciplinary group treatment for fecal incontinence in children (called “Poop group” by investigators) is a promising alternative for up to 60% of patients who fail to respond to standard care.
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